Efficacy and safety of latanoprost versus pilocarpine/timolol maleate fixed combination in patients with primary open-angle glaucoma or ocular hypertension

Acta Ophthalmologica
Józef KałuznyW C Stewart

Abstract

This study aimed to compare the safety and effect on intraocular pressure (IOP) of latanoprost given every evening versus pilocarpine/timolol maleate fixed combination (PTFC) given twice daily in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH). Following a 6-week, medicine-free period, qualified patients were randomized for Period 1 to either placebo administered every morning and latanoprost every evening or to PTFC administered twice daily. After 8 weeks of treatment, IOP was measured at 08.00, 10.00, 16.00 and 18.00 hours. Patients were then switched to the opposite treatment and underwent a second diurnal evaluation at the end of Period 2. Thirty-two patients completed this study. They demonstrated diurnal baseline IOP of 24.1 +/- 2.4 mmHg. Mean diurnal pressure was 16.8 +/- 2.1 mmHg on PTFC and 16.9 +/- 2.5 mmHg on latanoprost (p = 0.60). No statistical difference between treatments was observed at any individual time-point except at 10.00 hours, when the PTFC group demonstrated an IOP of 15.9 +/- 2.3 mmHg and latanoprost 16.8 +/- 2.7 mmHg (p = 0.02). There were no statistical differences between groups in unsolicited systemic or ocular adverse events (p > 0.05). However, the PTFC group showed ...Continue Reading

References

Aug 1, 1994·Acta Ophthalmologica·R J Uusitalo, A Palkama
May 8, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T K MundorfW C Stewart
Sep 3, 2002·Survey of Ophthalmology·Michael DiestelhorstCarol B Toris

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