Efficacy and Safety of Levetiracetam and Carbamazepine as Monotherapy in Partial Seizures

Epilepsy Research and Treatment
Swaroop Hassan SureshNithin Kumar

Abstract

Introduction. Levetiracetam (LEV) is a newer antiepileptic drug with better pharmacokinetic profile. Currently, it is frequently used for the treatment of partial seizures. The present study was undertaken to compare the efficacy and safety of LEV and Carbamazepine (CBZ) in partial epilepsy. Methods. This was a prospective, open labeled, randomized study. It was conducted in participants suffering from partial seizures after the approval of ethics committee and written informed consent. The first group received Tab LEV (500 to 3000 mg/day) and the second group received Tab CBZ (300 to 600 mg/day). The primary outcomes were efficacy and safety. The secondary outcome was the Quality of Life (QOL). Efficacy was assessed by comparing the seizure freedom rates at the end of 6 months. Safety profile was evaluated by comparing the adverse effects. QOL was assessed by QOLIE-10 scale. Results. The overall seizure freedom rate at the end of 6 months was 71.42% in CBZ group compared to 78.57% in LEV group (p = 0.2529). Both LEV and CBZ reported a similar incidence of adverse reactions. LEV group reported more behavioral changes like increased aggression and anxiety. Also, it showed better QOL compared to the CBZ group. Conclusion. LEV mon...Continue Reading

References

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Oct 10, 2014·Indian Journal of Pharmacology·Nithin KumarSuhas Chandran

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Citations

Jul 1, 2017·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
Dec 16, 2017·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
Dec 13, 2016·Journal of Comparative Effectiveness Research·Adedunni OlusanyaMustafa Danesi

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