Efficacy and safety of long-term oral flecainide acetate in patients with responsive supraventricular tachycardia

The American Journal of Cardiology
K J Hellestrand

Abstract

In 102 patients with inducible supraventricular tachycardia (SVT), 56 women and 46 men aged 20-86 (mean, 52) years, underwent electrophysiologic study. SVTs observed at electrophysiologic study were atrial flutter or atrial fibrillation (32%), the "slow-fast" form of atrioventricular (AV) nodal reentrant tachycardia (45%), orthodromic AV reentrant tachycardia (25%), and atrial tachycardia (9%). More than 1 SVT occurred in some patients. Spontaneous symptomatic SVT frequency prior to oral flecainide varied from 3/day to 1/3 months (mean, 3/month). At electrophysiologic study and during SVT, intravenous flecainide, 2 mg/kg body weight, was given at an infusion rate of 10 mg/min up to a maximum dose of 150 mg. Patients were commenced on oral flecainide if SVT termination occurred during intravenous flecainide administration and if reinitiation was not possible after the total dose of flecainide had been given. In patients with AV nodal reentrant tachycardia and AV reentrant tachycardia further criteria for commencing oral flecainide were SVT termination by ventricular-atrial conduction block and persistent ventricular-atrial block after intravenous flecainide administration. Initial oral flecainide dosage was determined by assessi...Continue Reading

Citations

Mar 10, 2006·The New England Journal of Medicine·Etienne Delacrétaz
Mar 21, 2009·Journal of Cardiovascular Electrophysiology·Mubashir AhmedM Eyman Mortada
May 13, 2009·Expert Opinion on Drug Safety·Knut Gjesdal
Mar 8, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Hanney Gonna, Mark M Gallagher
Apr 17, 2021·BMJ Case Reports·Dilpat KumarPrashant Patel

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