Efficacy and safety of low-dose celecoxib in reducing post-operative paralytic ileus after major abdominal surgery

ANZ Journal of Surgery
Devinder P RajuDavid A Wattchow

Abstract

A number of interventions have been used to decrease the incidence of post-operative paralytic ileus. A secondary outcome of a randomized controlled study showed that COX-2 inhibitors decreased the incidence of paralytic ileus. We sought to study a large cohort of patients undergoing major abdominal operations who were treated with a COX-2 inhibitor. This is a retrospective review of prospectively collected data. All eligible patients were given a COX-2 inhibitor--celecoxib 100 mg--twice daily starting on the day of surgery until the seventh day post-operatively or discharge, whichever was earlier. The rate of paralytic ileus was calculated and compared with historical data. Secondary outcome measures were the effect of using COX-2 inhibitors on renal function, electrolytes and haemoglobin, morbidity and leak rates. Two hundred and fifty-two patients were treated with celecoxib; the control arm consisted of 67 historical patients. Of the 252 patients, we had complete data for 235 patients and ileus in 17 patients (7.23%) compared with 13.4% in the control group (P = 0.05). Subgroup analysis showed ileus in 5.45% of colectomy patients and 6.36% of patients who have had a colectomy and high anterior resection. There was no detrim...Continue Reading

References

Sep 11, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J Bauer, G E Boeckxstaens
Feb 17, 2005·The New England Journal of Medicine·Scott D SolomonUNKNOWN Adenoma Prevention with Celecoxib (APC) Study Investigators
Mar 25, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H FukudaT Takahashi
Aug 22, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S E NoblettA F Horgan
Mar 27, 2007·Journal of the American College of Surgeons·Bruce G WolffLee Techner
Oct 18, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Anthony J Senagore
Mar 11, 2008·Lancet·Henrik Kehlet
Jun 10, 2008·Diseases of the Colon and Rectum·Kamran Zargar-ShoshtariAndrew G Hill
Feb 10, 2012·The British Journal of Surgery·K J GorissenM D P Luyer

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Citations

Dec 1, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·David WattchowMarcello Costa
Feb 10, 2021·The Journal of Obstetrics and Gynaecology Research·Jordan MattsonEmily K Hill

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