Abstract
We performed a prospective observational study comparing the efficacy and safety of low-dose ganciclovir (5 mg/kg/day) as initial preemptive therapy in allogeneic haematopoietic stem cell transplantation (HSCT) recipients with conventional-dose ganciclovir (10 mg/kg/day). All adult patients undergoing allogeneic HSCT were enrolled at a transplant centre over a 24 month period. The decision to use low-dose or conventional-dose ganciclovir was at the discretion of each attending haematologist. A logistic regression model with inverse probability of treatment weighting (IPTW) using propensity scores was performed to reduce the effect of the selection bias in assignment for ganciclovir preemptive therapy. Of the 252 HSCT recipients, 97 (38%) received preemptive ganciclovir therapy. Of these, 53 (55%) and 44 (45%) received low-dose and conventional-dose ganciclovir, respectively. The viral clearance rate was higher in the low-dose ganciclovir group [98% (52/53)] than in the conventional-dose ganciclovir group [86% (38/44), P = 0.04], while the low-dose ganciclovir group exhibited a longer viral clearance time (median 21.0 days) than the conventional-dose ganciclovir group (median 14.0 days, P = 0.05). The rate of discontinuation of ...Continue Reading
References
Feb 1, 1993·Annals of Internal Medicine·J M GoodrichJ D Meyers
Jul 15, 1997·Transplantation·M BoeckhR A Bowden
Nov 5, 1998·Statistics in Medicine·R B D'Agostino
Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Oct 24, 2000·Bone Marrow Transplantation·R K AveryB J Bolwell
Apr 21, 2001·Bone Marrow Transplantation·Y KandaY Takaue
Jan 30, 2002·The Journal of Antimicrobial Chemotherapy·Paul D Griffiths
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanCarlos Paya
Jun 1, 2002·Bone Marrow Transplantation·T MoriY Ikeda
Jan 10, 2003·Statistics in Medicine·Ralph B D'AgostinoLisa M Sullivan
Apr 16, 2003·British Journal of Haematology·Akira TomonariShigetaka Asano
Sep 18, 2003·Bone Marrow Transplantation·R VijJ F DiPersio
Jun 24, 2004·Statistics in Medicine·Michael J Pencina, Ralph B D'Agostino
Nov 15, 2005·Bone Marrow Transplantation·L A VerkruyseR Vij
Nov 6, 2007·Bone Marrow Transplantation·A TomonariS Asano
Mar 21, 2009·Blood·Michael Boeckh, Per Ljungman
May 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eun-Young JangSung-Han Kim
May 11, 2010·International Journal of Hematology·Seung Tae KimChul Won Jung
May 15, 2010·Infectious Disease Clinics of North America·Per LjungmanMichael Boeckh
Jun 11, 2011·The Journal of Clinical Investigation·Michael Boeckh, Adam P Geballe
Jul 1, 2011·The Korean Journal of Internal Medicine·Dong-Gun LeeJung-Hyun Choi
Citations
Nov 28, 2012·Bone Marrow Transplantation·P HiwarkarW Qasim
Jan 18, 2013·The Journal of Antimicrobial Chemotherapy·So-Youn ParkSang-Oh Lee
Dec 12, 2012·Antimicrobial Agents and Chemotherapy·So-Youn ParkSung-Han Kim
Apr 5, 2016·Expert Review of Hematology·Enrico MaffiniBenedetto Bruno
Apr 5, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·H Y JuH S Ahn
Apr 9, 2016·The Korean Journal of Internal Medicine·Tark KimSung-Han Kim
Nov 1, 2016·Expert Review of Hematology·Franco LocatelliPietro Merli
Apr 28, 2018·PLoS Neglected Tropical Diseases·Marta S PalmeirimJennifer Keiser
Jan 10, 2020·BMJ Open·Anne-Grete MärtsonJan-Willem C Alffenaar
Aug 24, 2017·The Korean Journal of Internal Medicine·Sung-Han KimDuck-Jong Han
Jan 31, 2021·Clinical Pharmacokinetics·Philip Roland SelbyJason A Roberts
Aug 25, 2019·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Wei LuFu-Der Wang
Jun 3, 2021·Vaccines·Sara ScarpiniMarcello Lanari