Efficacy and safety of mirodenafil in men taking antihypertensive medications

The Journal of Sexual Medicine
Jae-Seung PaickDae Yul Yang

Abstract

Mirodenafil is a recently developed oral phosphodiesterase type 5 inhibitor, which was observed to significantly improve erectile function and was well tolerated in men with broad-spectrum erectile dysfunction (ED). To investigate the efficacy and safety of mirodenafil treatment compared with placebo in men taking at least one antihypertensive medication. A multicenter, double-blind, placebo-controlled, parallel group, fixed-dose study was conducted with 109 subjects who were randomized to placebo or mirodenafil 100 mg for 12 weeks on an "as needed" basis. The primary efficacy measures were the changes from baseline in sum of scores on International Index of Erectile Function-erectile function domain (IIEF-EF) questions 1 to 5 and 15 with treatment. The secondary efficacy measures included scores on IIEF question 3 and 4 (Q3 and Q4), all domain scores of IIEF, and Sexual Encounter Profile Question 2 and 3 (SEP2 and SEP3) along with responses to Global Assessment Question (GAQ) and Life Satisfaction Checklist (LSC). The safety assessments included laboratory tests, vital signs, 12-lead electrocardiogram recordings, and patients' reporting of adverse events. The mirodenafil group showed significantly greater increase in IIEF-EF s...Continue Reading

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Citations

Aug 28, 2014·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jinhong LiPing Han
Nov 9, 2010·Biochimica Et Biophysica Acta·Annamaria MorelliLuciano Adorini
Sep 30, 2016·Expert Opinion on Pharmacotherapy·Igor VoznesenskyWayne J G Hellstrom
Apr 2, 2016·Therapeutic Advances in Urology·Min Chul Cho, Jae-Seung Paick
May 30, 2014·The World Journal of Men's Health·Hyun Jun ParkNam Cheol Park
May 10, 2013·Expert Review of Clinical Pharmacology·Stefan ÜckertMatthias Oelke
Nov 14, 2013·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Wan DuHui Ding
Aug 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nelisiwe Prenate MasukuSogolo Lucky Lebelo

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