Efficacy and safety of monotherapy by pegvisomant, a growth hormone receptor antagonist, in Japanese patients with acromegaly

Endocrine Journal
Akira ShimatsuKazuo Chihara

Abstract

Pegvisomant is a GH receptor antagonist and strong inhibitor of insulin-like growth factor I (IGF-I) production. The treatment goal for acromegaly is to normalize serum IGF-I levels and attenuate associated symptoms. The efficacy and safety of pegvisomant as treatment for acromegaly have been reported in Caucasians, but not in Japanese. Here we report the clinical experience of using pegvisomant in Japanese patients with acromegaly. The efficacy and safety data for pegvisomant from two open-labeled clinical studies in Japan, conducted from 2004 to 2007, were re-analyzed using the new Japanese age- and sex-matched normative ranges for IGF-I. Eighteen patients with active acromegaly were enrolled in an initial pivotal study, and 16 of them were moved to a long-term (max 168 weeks) extension study. The dose of pegvisomant in the extension study was adjusted to 10-30 mg per day according to IGF-I levels. IGF-I normalization was observed in 81.3% (13/16 patients) during the extension study. The mean percentage decrease from baseline in serum IGF-I level was 64.7% at the time of last observation. The clinical symptoms and overall health status were improved, and the ring size was reduced over time until Week 12 and maintained. For sa...Continue Reading

References

Oct 13, 1998·The Journal of Clinical Endocrinology and Metabolism·B SwearingenN T Zervas
Apr 20, 2000·The New England Journal of Medicine·P J TrainerR J Davis
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·David R ClemmonsMichael O Thorner
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ian M HoldawayGreg D Gamble
Feb 27, 2007·European Journal of Endocrinology·A N PaisleyP J Trainer
Jun 6, 2008·European Journal of Endocrinology·I M HoldawayG D Gamble
Jul 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Vivien S BonertShlomo Melmed
Nov 4, 2009·The Journal of Clinical Investigation·Shlomo Melmed
Mar 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Ignacio BernabeuFelipe F Casanueva
Jul 29, 2011·The Journal of Clinical Endocrinology and Metabolism·Anne Marij G BurgersOlaf M Dekkers
Mar 1, 2012·The Journal of Clinical Endocrinology and Metabolism·A J van der LelyMaria Koltowska-Häggström
Oct 31, 2014·The Journal of Clinical Endocrinology and Metabolism·Laurence KatznelsonJohn A H Wass
Mar 17, 2015·The Journal of Clinical Investigation·Cuiqi ZhouShlomo Melmed

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Citations

Oct 17, 2018·European Journal of Endocrinology·Michael BuchfelderJuliana H Hey-Hadavi
Jan 1, 2017·Expert Review of Endocrinology & Metabolism·Ludovica F S GrassoAnnamaria Colao
Nov 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Leonie H A BroersenNienke R Biermasz

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