DOI: 10.1101/19008672Oct 16, 2019Paper

Efficacy and safety of Nab-paclitaxel in breast cancer: a meta-analysis

MedRxiv : the Preprint Server for Health Sciences
U. YadavVandana Rai

Abstract

Worldwide breast cancer is the leading cause of cancer related death in women. Paclitaxel is an effective drug used for the treatment of breast cancer but it has many side effects. Nab-paclitaxel (nanoparticle albumin-bound paclitaxel) is an FDA approved drug for the treatment of breast cancer. Currently many clinical trials are conducted to deliver nab-paclitaxel into the tumor cells. But the efficacy and safety of this nab-paclitaxel over conventional paclitaxel still remains questionable. So, we performed a meta-analysis to evaluate the efficacy and safety of nab-paclitaxel in breast cancer treatment. Electronic databases were searched for the suitable studies using key terms 'nab-paclitaxel', 'paclitaxel', and 'clinical trial' with the combination of 'breast cancer' up to August 11, 2019. Risk ratio (RR) and odds ratio (OR) with corresponding 95% confidence intervals (CIs) were calculated. All statistical analyses were performed by the Open Meta-Analyst program. A total of eight studies which fulfilled our criteria were included in this study. For efficacy we retrieved data of 12 months progression free survival, 24 months progression free survival, and overall survival (up to 3 years) and for the safety we took data of nau...Continue Reading

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