Efficacy and safety of once-daily oxybutynin patch versus placebo and propiverine in Japanese patients with overactive bladder: A randomized double-blind trial

International Journal of Urology : Official Journal of the Japanese Urological Association
Osamu YamaguchiOxybutynin Patch Study Group

Abstract

To evaluate the efficacy and safety of once-daily oxybutynin patch therapy for overactive bladder. A randomized double-blind trial was carried out in patients with overactive bladder syndrome, who received an oxybutynin patch, propiverine (20 mg) or placebo once daily for 12 weeks. The primary efficacy end-point was the change of the mean daily number of micturitions in week 12. A total of 1530 patients were randomized to receive the oxybutynin patch (573), propiverine (576) or placebo (381). The change of the mean daily frequency of micturition from baseline in the full analysis set was -1.89 ± 2.04 with the oxybutynin patch, which was significantly higher than with placebo (-1.44 ± 2.23) (P = 0.0015). The difference of the mean change in the mean daily number of micturitions between the oxybutynin patch and propiverine groups showed a 95% confidence interval of -0.28 to 0.21, and the upper limit of this interval was below the predefined non-inferiority margin of 0.37, showing non-inferiority of the oxybutynin patch to propiverine. The incidence of dry mouth and constipation was higher with propiverine than with the oxybutynin patch or placebo. Application site dermatitis was more frequent with the oxybutynin patch (31.8%) tha...Continue Reading

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Citations

Jul 28, 2015·Psychosomatics·Jonathan R StevensTheodore A Stern
Mar 18, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Osamu YokoyamaYu Masegi
Aug 9, 2016·Actas dermo-sifiliográficas·M Bergón-SendínR Suárez-Fernández
Apr 2, 2016·Therapeutic Advances in Urology·Joshua A CohnRoger R Dmochowski
Jan 16, 2018·F1000Research·Bronagh McDonnell, Lori Ann Birder
Jan 28, 2016·Current Opinion in Urology·Calvin LeeMargot S Damaser
Sep 5, 2020·Research and Reports in Urology·Raúl Vozmediano-ChicharroBlanca Madurga-Patuel
Jan 11, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Javier L Arenas, D Duane Baldwin
Jul 24, 2018·Therapeutic Advances in Urology·Karl-Erik AnderssonPhilip Van Kerrebroeck
Jan 21, 2016·Lower Urinary Tract Symptoms·Satoru TakahashiMasayasu Koyama
May 18, 2019·Current Urology Reports·Ahmed El-Zawahry
Mar 3, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru TakahashiTsuyoshi Yoshizawa
May 31, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Toshiro SuzukiOsamu Ishizuka

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