Abstract
Advanced-stage cancer patients often suffer from anemia that closely resembles the anemia of chronic inflammatory diseases characterized by specific changes in iron homeostasis and absorption. i.v. iron improves the efficacy of recombinant human erythropoietin (rHuEPO) in anemic cancer patients undergoing chemotherapy. We report the results of an open-label, randomized, prospective trial aimed at testing the efficacy and safety of treatment with oral lactoferrin versus i.v. iron, both combined with rHuEPO, for the treatment of anemia in a population of 148 advanced cancer patients undergoing chemotherapy. All patients received s.c. rHuEPO-beta, 30,000 UI once weekly for 12 weeks, and were randomly assigned to ferric gluconate (125 mg i.v. weekly) or lactoferrin (200 mg/day). Both arms showed a significant hemoglobin increase. No difference in the mean hemoglobin increase or the hematopoietic response, time to hematopoietic response, or mean change in serum iron, C-reactive protein, or erythrocyte sedimentation rate were observed between arms. In contrast, ferritin decreased in the lactoferrin arm whereas it increased in the i.v. iron arm. In conclusion, these results show similar efficacy for oral lactoferrin and for i.v. iron,...Continue Reading
References
Jun 14, 1990·The New England Journal of Medicine·C B MillerJ L Spivak
Oct 8, 1999·Journal of the National Cancer Institute·J E Groopman, L M Itri
Jun 20, 2001·Cancer·J J CaroG Goss
Mar 29, 2003·Blood·Tomas Ganz
Oct 25, 2003·Lancet·Michael HenkeHermann Frommhold
Nov 13, 2003·Seminars in Oncology·Brian Leyland-Jones, Joyce A O'shaughnessy
Mar 31, 2004·The American Journal of Medicine·Kevin KnightLodovico Balducci
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael AuerbachJeevindra Rana
May 5, 2004·The Journal of Clinical Investigation·Nancy C Andrews
Jun 29, 2004·International Journal of Cancer. Journal International Du Cancer·Atul VaradhacharyFederica Pericle
Jun 30, 2004·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Heather M Baker, Edward N Baker
Mar 11, 2005·The New England Journal of Medicine·Guenter Weiss, Lawrence T Goodnough
Mar 19, 2005·Blood·Antonio MacciòGiovanni Mantovani
Jun 21, 2005·Nature Reviews. Cancer·Jerry L Spivak
Jun 22, 2005·The Oncologist·Mei Sheng DuhRoger J Waltzman
Nov 25, 2005·Stem Cells and Development·J ArtymM L Kruzel
Feb 14, 2006·The American Journal of Clinical Nutrition·Bo Lönnerdal, Annika Bryant
Feb 14, 2007·The Oncologist·David H HenryLeslie R Laufman
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey S WolfBert W O'Malley
May 8, 2007·Lancet·Michael AuerbachJohn Glaspy
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Douglas RizzoUNKNOWN American Society of Hematology
Mar 4, 2008·JAMA : the Journal of the American Medical Association·Charles L BennettMichael Henke
Mar 14, 2008·Seminars in Arthritis and Rheumatism·Dominic S C Raj
Apr 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurent BastitJohan F Vansteenkiste
Apr 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paolo PedrazzoliSalvatore Siena
Jul 4, 2008·Journal of the National Comprehensive Cancer Network : JNCCN·George M RodgersUNKNOWN National Comprehensive Cancer Network
Jul 22, 2008·Cancer·David CellaJoel D Kallich
Oct 10, 2008·International Journal of Antimicrobial Agents·Susana A González-ChávezQuintín Rascón-Cruz
Jan 29, 2009·Biochemical Pharmacology·Isabelle BuckMarc Diederich
May 5, 2009·Lancet·Julia BohliusAndreas Engert
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brandon K Hadland, Gregory D Longmore
Citations
Sep 24, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antonio Macciò, Clelia Madeddu
Aug 21, 2013·BMJ : British Medical Journal·Edward LittonKwok M Ho
Oct 6, 2011·Journal of Cancer Research and Clinical Oncology·Fausto PetrelliSandro Barni
Oct 18, 2012·Expert Opinion on Pharmacotherapy·Antonio MacciòGiovanni Mantovani
May 29, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jagat R KanwarRupinder K Kanwar
Sep 12, 2015·Expert Opinion on Investigational Drugs·Ugo TestaPelosi Elvira
Mar 17, 2016·Antioxidants & Redox Signaling·Sylvain MayeurEmile Levy
Oct 24, 2012·Anemia·Antonio Macciò, Clelia Madeddu
Dec 3, 2014·Anaesthesia·B Clevenger, T Richards
Nov 27, 2014·Frontiers in Immunology·Nataša DebeljakArthur J Sytkowski
Apr 29, 2016·European Journal of Heart Failure·Ben ClevengerToby Richards
Aug 30, 2017·Asia-Pacific Journal of Clinical Oncology·Vanita NoronhaKumar Prabhash
Feb 5, 2016·The Cochrane Database of Systematic Reviews·Rahul MhaskarBenjamin Djulbegovic
Jan 1, 2015·The Cochrane Database of Systematic Reviews·Kurinchi Selvan GurusamyToby Richards
Nov 20, 2014·Nutrition Reviews·Yunlei ZhangLigia R Rodrigues
Dec 11, 2019·Immunology·Antonio Macciò, Clelia Madeddu
Jan 1, 2014·International Scholarly Research Notices·Tarek M MoastafaMai Salah El-Din Koura
Oct 9, 2018·Frontiers in Physiology·Clelia MadedduAntonio Macciò
Nov 6, 2017·Annals of Hematology·Nathan VisweshwarKenneth Zuckerman
Jan 29, 2021·Critical Reviews in Food Science and Nutrition·Yaxing ManBo Wang
Feb 9, 2021·Journal of Ovarian Research·Antonio MacciòClelia Madeddu
Feb 5, 2021·Nutrients·Valentina NatalucciRita Emili
Apr 4, 2021·International Journal of Molecular Sciences·Antonio MaccioClelia Madeddu
Jul 2, 2021·Journal of Experimental Pharmacology·Clelia MadedduAntonio Macciò
Nov 13, 2021·JAMA Network Open·Akshay A ShahSimon J Stanworth
Feb 1, 2011·European Urology·Giuseppe Di LorenzoCarlo Buonerba