Efficacy and Safety of Oral TDF-Based Pre-exposure Prophylaxis for Men Who Have Sex With Men: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology
Xiaojie HuangHao Wu

Abstract

Background: Pre-exposure prophylaxis (PrEP) is used as an HIV prevention method by people at substantial risk of HIV infection. This systematic review and meta-analysis evaluates current clinical evidence for use of oral TDF-based PrEP among men who have sex with men. Methods: A comprehensive literature search in PubMed, web of science, Google Scholar and ClinicalTrials.gov was performed. A random-effects meta-analysis was conducted using the event rate (ER) for estimation of the incidence of HIV and grade 3 or 4 adverse events (AE) among PrEP arm and using risk ratio (RR) for comparison of incidence of HIV and grade 3 or 4 AE between PrEP recipients and PrEP non-users. Blood-based adherence levels were also divided into three categories with reference to previous meta-analysis. Subgroup meta-analysis was also performed to evaluate whether blood-based adherence levels moderated the effect of TDF-based PrEP on HIV incidence. Narrative review was used due to inconsistent measurements of risk behavior and drug resistance. This review is registered on the PROSPERO database (CRD42017077965). Results: Fourteen studies were included in the review. Oral TDF-based PrEP significantly reduced HIV incidence with minimum drug resistance and...Continue Reading

References

Jan 1, 1995·Sexually Transmitted Diseases·J M ZenilmanD Celentano
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Nov 26, 2010·The New England Journal of Medicine·Robert M GrantUNKNOWN iPrEx Study Team
Aug 10, 2011·PloS One·Joseph PrejeanUNKNOWN HIV Incidence Surveillance Group
Mar 8, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lisa A GrohskopfSusan P Buchbinder
Oct 19, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sybil G HosekUNKNOWN Adolescent Trials Network for HIVAIDS Interventions (ATN)
May 24, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christina PsarosSteve A Safren
Sep 4, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan E VolkC Bradley Hare
Dec 2, 2015·The New England Journal of Medicine·Jean-Michel MolinaUNKNOWN ANRS IPERGAY Study Group
Dec 15, 2015·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Karen S IngersollSharzad Hosseinbor
Jul 15, 2016·Lancet·Chris BeyrerKenneth H Mayer
Sep 16, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sybil G HosekUNKNOWN Adolescent Trials Network (ATN) for HIVAIDS Interventions
May 16, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samuel M JennessEli S Rosenberg
Jun 10, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Astrid M NewsumUNKNOWN MOSAIC collaborators
Sep 14, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Raphael J LandovitzAmy Rock Wohl
Dec 13, 2017·BMJ : British Medical Journal·Monica DesaiSheena McCormack

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Citations

Feb 7, 2019·Journal of the International AIDS Society·Jing HanFujie Zhang
Jun 18, 2019·The Journal of the Association of Nurses in AIDS Care : JANAC·Steven MaxwellMaryam Shahmanesh
Mar 4, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Patrick AhausAdriane Skaletz-Rorowski
Jun 27, 2019·The Journal of the Association of Nurses in AIDS Care : JANAC·Steven MaxwellMaryam Shahmanesh
Feb 23, 2020·International Journal of STD & AIDS·Steven MaxwellOliver Stirrup
Jul 26, 2019·International Journal of Environmental Research and Public Health·Liping PengJinghua Li
Aug 14, 2019·The American Journal of Nursing·Jeffrey Kwong
Oct 3, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ross CromartyDerseree Archary
Oct 24, 2020·Chinese Medical Journal·Jun-Jie XuHong Shang
Nov 13, 2020·AIDS Research and Treatment·Ross Cromarty, Derseree Archary
Dec 5, 2020·Chinese Medical Journal·Jun-Jie XuHong Shang
May 8, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rute NunesJosé das Neves

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Clinical Trials Mentioned

NCT01632995

Software Mentioned

iPrEx OLE
Google Scholar
Comprehensive Meta - Analysis ( CMA )

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