Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Savino BrunoPatrick Marcellin

Abstract

The objective of this study is to determine the efficacy and safety of peginterferon alfa-2a (40 KD)/ribavirin in patients with advanced fibrosis. Data from 341 genotype 1/4 patients (99 with bridging fibrosis/cirrhosis) treated for 48 weeks and 1547 genotype 2/3 patients (380 with bridging fibrosis/cirrhosis) treated for 16 or 24 weeks enrolled in three randomized international studies were analyzed. Sustained virological response (SVR) rates decreased progressively from 60% in genotype 1/4 patients without advanced fibrosis to 51% in those with bridging fibrosis and 33% in those with cirrhosis (trend test P = 0.0028); and from 76% to 61% and 57%, respectively, in genotype 2/3 patients treated for 24 weeks (trend test P < 0.0001). Irrespective of genotype, patients without advanced fibrosis were more likely to have an earlier response to treatment that was associated with higher SVR rates and lower relapse rates during untreated follow-up. Among patients with or without a diagnosis of advanced fibrosis, rates of SVR and relapse were similar for patients with similar responses in the first 12 weeks. Compared with patients with less severe disease, SVR rates are significantly lower in patients with advanced fibrosis. However, ir...Continue Reading

References

Dec 7, 2000·The New England Journal of Medicine·E J HeathcoteJ De Pamphilis
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 9, 2002·American Journal of Epidemiology·Joshua A SalomonSue J Goldie
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Nov 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olav DalgardHelge Bell
Jan 20, 2005·Annals of Internal Medicine·Yasushi ShiratoriUNKNOWN Tokyo-Chiba Hepatitis Research Group
Jun 24, 2005·The New England Journal of Medicine·Alessandra MangiaAngelo Andriulli
Aug 27, 2005·The Lancet Infectious Diseases·Colin W ShepardMiriam J Alter
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donald M JensenBernard Willems
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Savino BrunoUNKNOWN Italian Association of the Study of the Liver Disease (AISF)
Jul 13, 2007·The New England Journal of Medicine·Mitchell L ShiffmanUNKNOWN ACCELERATE Investigators
Oct 19, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sanaa M KamalMohamed Abdelaziz
Nov 3, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olav DalgardUNKNOWN North-C Group
Dec 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alessandra MangiaAngelo Andriulli
May 28, 2008·Gastroenterology·Peter FerenciUNKNOWN Austrian Hepatitis Study Group

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Citations

Oct 5, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Kosh Agarwal, Ashley Barnabas
Feb 15, 2011·Clinical Therapeutics·Elena VezaliMassimo Colombo
Jul 21, 2010·Nature Reviews. Gastroenterology & Hepatology·Alessio AghemoMassimo Colombo
Sep 8, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·José A MiraJuan A Pineda
Nov 28, 2012·World Journal of Gastroenterology : WJG·Qiuwei PanRobert J de Knegt
Aug 29, 2013·World Journal of Gastroenterology : WJG·Mariarosa TamèGiuseppe Mazzella
Aug 11, 2012·Hepatitis Monthly·Roberta D'Ambrosio, Alessio Aghemo
Mar 25, 2014·World Journal of Gastroenterology : WJG·Nobuyuki ToshikuniMikihiro Tsutsumi
Oct 15, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Barbara CocoUNKNOWN Review Board:
Jan 25, 2011·Digestive Diseases and Sciences·Stevan A Gonzalez
Sep 13, 2011·Expert Review of Anti-infective Therapy·Maria Ripoli, Valerio Pazienza
Mar 9, 2012·Expert Review of Anti-infective Therapy·Paul M TremblingGeoffrey M Dusheiko
Oct 6, 2015·Expert Review of Clinical Pharmacology·Vincenzo BoccaccioSavino Bruno
May 24, 2012·Expert Opinion on Investigational Drugs·Sudeep TanwarGeoffrey M Dusheiko
Jan 22, 2011·Expert Opinion on Biological Therapy·Elena VezaliMassimo Colombo
Dec 14, 2011·European Journal of Internal Medicine·Ahmed A el-KhattibMoataz M Sayed
Apr 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michelle Lai, Nezam H Afdhal
Jan 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marie-Luise BerresHermann E Wasmuth
Dec 21, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideyuki TamaiMasao Ichinose
Apr 21, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Natalie BzowejUNKNOWN PHOENIX Study Group
Jan 22, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·
Nov 11, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Raymond T ChungAdrian M Di Bisceglie
Nov 19, 2010·Alimentary Pharmacology & Therapeutics·P Guillouche, C Féray
Feb 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Phil McEwanGilbert L'italien
Jun 30, 2012·Journal of Gastroenterology and Hepatology·José-Luis CallejaUNKNOWN Management of HCV Infection and Normal Transaminases Spanish Study Group
Jan 11, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Bruno Roche, Didier Samuel
Jan 11, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Marc BourlièrePaul Castellani
Jan 11, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Eleonora Grassi, Alessio Aghemo
Dec 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lisa J McGarryMilton C Weinstein
Jan 1, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Vincenzo Boccaccio, Savino Bruno
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K Sterling
May 23, 2014·Alimentary Pharmacology & Therapeutics·V W-S Wong, C-J Liu
Mar 25, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Eirini I Rigopoulou, George N Dalekos
Jun 24, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Angelo AndriulliUNKNOWN Collaborators

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