Efficacy and safety of perampanel oral loading in postanoxic super-refractory status epilepticus: A pilot study

Epilepsia
Simone BerettaCarlo Ferrarese

Abstract

Refractory nonconvulsive status epilepticus (NCSE) occurs in 10%-30% of patients following resuscitation after cardiac arrest. Both the optimal treatment and prognosis of postanoxic status epilepticus remain uncertain. We analyzed acute electroencephalographic changes, neurological outcome at 3 months, and adverse effects in consecutive postanoxic patients with super-refractory NCSE treated with add-on oral loading of perampanel. Eight postanoxic patients with super-refractory NCSE were treated with perampanel (dose range = 6-12 mg). All patients had continuous electroencephalographic monitoring showing definite generalized NCSE and favorable multimodal prognostic indicators (presence of brainstem reflexes, presence of bilateral N20 responses, absence of periodic discharges/generalized epileptic periodic discharges). In six patients (75%), status epilepticus resolved within 72 hours after administration of perampanel, without changing the comedication. Neurological outcomes at 3 months were return to normal or minimal disability in four patients (50%). A mild cholestatic liver injury, which required no specific treatment, was observed in five patients (62.5%). Perampanel 6-12 mg oral loading appeared to be an effective option i...Continue Reading

References

Jul 3, 2010·Stroke; a Journal of Cerebral Circulation·Michael MlynashChristine A C Wijman
May 6, 2011·Clinical Pharmacology and Therapeutics·G P AithalA K Daly
Nov 8, 2011·Annals of Intensive Care·Nicolas MongardonAlain Cariou
Feb 22, 2012·Critical Care Medicine·Romergryko G GeocadinRonald M Lazar
Jul 26, 2012·Annals of Neurology·Karthik RajasekaranJaideep Kapur
Mar 13, 2014·Epilepsy Research·Tobias LoddenkemperFrances E Jensen
Mar 31, 2015·Epilepsy & Behavior : E&B·Juliane RedeckerJohannes Rösche
Aug 20, 2015·Epilepsy & Behavior Case Reports·Estevo SantamarinaXavier Salas-Puig
Dec 3, 2015·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Andrea O Rossetti
Mar 28, 2016·Lancet Neurology·Andrea O RossettiMauro Oddo
Aug 25, 2016·Resuscitation·Edilberto AmorimUNKNOWN Post Cardiac Arrest Service

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Citations

Mar 12, 2019·Current Opinion in Critical Care·Baxter Allen, Paul M Vespa
Oct 1, 2019·Case Reports in Critical Care·Christopher R NeweyPravin George
Dec 11, 2020·Neurology. Clinical Practice·Andrea StabileLeonello Avalli
Mar 6, 2021·Current Opinion in Neurology·Andrea O Rossetti, Vincent Alvarez
Mar 16, 2021·Epilepsy Currents·Juan G OchoaDavid G Vossler
Jun 2, 2021·Annals of the New York Academy of Sciences·Alyson KatzJason Q Lam
Jul 6, 2021·Aging and Disease·Batool F KirmaniRobert J Delorenzo

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