Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind, placebo-controlled pilot study

Critical Care Medicine
John W DevlinErik Garpestad

Abstract

To compare the efficacy and safety of scheduled quetiapine to placebo for the treatment of delirium in critically ill patients requiring as-needed haloperidol. Prospective, randomized, double-blind, placebo-controlled study. Three academic medical centers. Thirty-six adult intensive care unit patients with delirium (Intensive Care Delirium Screening Checklist score > or = 4), tolerating enteral nutrition, and without a complicating neurologic condition. Patients were randomized to receive quetiapine 50 mg every 12 hrs or placebo. Quetiapine was increased every 24 hrs (50 to 100 to 150 to 200 mg every 12 hrs) if more than one dose of haloperidol was given in the previous 24 hrs. Study drug was continued until the intensive care unit team discontinued it because of delirium resolution, therapy > or = 10 days, or intensive care unit discharge. Baseline characteristics were similar between the quetiapine (n = 18) and placebo (n = 18) groups. Quetiapine was associated with a shorter time to first resolution of delirium [1.0 (interquartile range [IQR], 0.5-3.0) vs. 4.5 days (IQR, 2.0-7.0; p =.001)], a reduced duration of delirium [36 (IQR, 12-87) vs. 120 hrs (IQR, 60-195; p =.006)], and less agitation (Sedation-Agitation Scale score ...Continue Reading

References

Sep 3, 1988·Lancet·F Huyse, R S van Schijndel
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus
Oct 1, 1995·Critical Care Medicine·J C MarshallW J Sibbald
Jan 1, 1994·The Journal of Neuropsychiatry and Clinical Neurosciences·M M PlattP B Jacobsen
May 20, 1998·The American Journal of Cardiology·N D SharmaJ E Tisdale
Oct 30, 1998·Journal of Psychiatric Research·M D Jibson, R Tandon
Jan 19, 1999·The American Journal of Psychiatry·A I Leshner
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·N S FreedmanR J Schwab
Jun 30, 2001·Intensive Care Medicine·N BergeronY Skrobik
Aug 10, 2001·Psychosomatics·R TorresR Kennedy
Aug 21, 2001·Intensive Care Medicine·M J DuboisY Skrobik
Jan 18, 2002·Intensive Care Medicine·E W ElyS K Inouye
Feb 6, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·UNKNOWN American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharm
Mar 21, 2002·Critical Care Medicine·Judith JacobiUNKNOWN Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), America
Apr 3, 2002·Psychosomatics·Laura Leso, Thomas L Schwartz
Jun 21, 2002·Psychosomatics·Thomas L Schwartz, Prakash S Masand
Jun 21, 2002·Psychosomatics·William BreitbartChristopher Gibson
Nov 21, 2002·Critical Care Medicine·Yoanna Skrobik
Mar 19, 2003·Journal of Geriatric Psychiatry and Neurology·Kye Y KimDebra Gropper
Dec 20, 2003·Intensive Care Medicine·Yoanna K SkrobikStewart B Gottfried
Mar 12, 2004·Primary Care Companion to the Journal of Clinical Psychiatry·Thomas L. Schwartz, Prakash S. Masand
Apr 9, 2004·Critical Care Medicine·Eric B MilbrandtE Wesley Ely
Apr 15, 2004·JAMA : the Journal of the American Medical Association·E Wesley ElyRobert S Dittus
Jul 16, 2005·International Journal of Geriatric Psychiatry·S E de RooijM Levi
Sep 3, 2005·Critical Care : the Official Journal of the Critical Care Forum·Jason W W ThomasonE Wesley Ely
Oct 20, 2005·JAMA : the Journal of the American Medical Association·Lon S SchneiderPhilip Insel
Mar 23, 2006·Journal of the American Geriatrics Society·Josh F PetersonE Wesley Ely
Jan 24, 2007·Psychiatry and Clinical Neurosciences·Takashi TakeuchiToru Nishikawa
Feb 8, 2007·The Journal of Clinical Psychiatry·Dallas P SeitzLouis T van Zyl
Jun 6, 2007·Intensive Care Medicine·Pratik PandharipandeE Wesley Ely
Oct 16, 2007·Anaesthesia and Intensive Care·U Prakanrattana, S Prapaitrakool
Dec 13, 2007·JAMA : the Journal of the American Medical Association·Pratik P PandharipandeE Wesley Ely
Feb 23, 2008·Critical Care : the Official Journal of the Critical Care Forum·John W DevlinYoanna Skrobik
Jun 17, 2008·Critical Care : the Official Journal of the Critical Care Forum·Timothy D GirardE Wesley Ely
Aug 19, 2008·Journal of Psychosomatic Research·Richard S BourneElizabeth L Sampson
Aug 19, 2008·Journal of Psychosomatic Research·Paula T TrzepaczShuyu Zhang
Dec 4, 2008·Critical Care Medicine·Margaret A PisaniSharon K Inouye

❮ Previous
Next ❯

Citations

Nov 16, 1994·JAMA : the Journal of the American Medical Association·E R MarcantonioT H Lee
Jun 7, 2012·JAMA : the Journal of the American Medical Association·Edward R Marcantonio
Jul 28, 2010·Intensive Care Medicine·Yoanna Skrobik
Mar 30, 2011·Intensive Care Medicine·David Bracco, Francesco Donatelli
Jan 25, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Dustin M Hipp, E Wesley Ely
Oct 22, 2013·Journal of Palliative Medicine·Gregory B CrawfordDavid C Currow
Jan 20, 2010·Critical Care Medicine·Aaron M JoffeDavid R Coursin
May 18, 2010·Critical Care Medicine·Timothy D GirardE Wesley Ely
Sep 21, 2012·Current Opinion in Psychiatry·Julius Popp, Sönke Arlt
Oct 22, 2011·American Journal of Respiratory and Critical Care Medicine·Shruti B Patel, John P Kress
Dec 29, 2012·Annals of Intensive Care·Rodrigo CavallazziPaul E Marik
Jun 30, 2011·Critical Care : the Official Journal of the Critical Care Forum·Ruth Y Y WanNicholas A Barrett
May 18, 2012·Critical Care : the Official Journal of the Critical Care Forum·Joshua T SwanKrista L Turner
Dec 22, 2012·Critical Care : the Official Journal of the Critical Care Forum·Salah G Keyrouz, Michael N Diringer
Jan 19, 2013·Critical Care : the Official Journal of the Critical Care Forum·Mark van den BoogaardPeter Pickkers
Mar 20, 2013·Critical Care : the Official Journal of the Critical Care Forum·Hao ZhangXue-Yin Shi
Aug 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Zaher Qassem, Eric B Milbrandt
Mar 14, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William Breitbart, Yesne Alici
Aug 9, 2013·Drug Design, Development and Therapy·Benchalak ManeetonKaweesak Chittawatanarat
Sep 8, 2011·Journal of Neurosciences in Rural Practice·Lisha Jenny JohnShoba Guido
Sep 27, 2013·Age and Ageing·Alasdair M J MaclullichColm Cunningham
Oct 10, 2013·American Journal of Respiratory and Critical Care Medicine·Andrew M NaidechE Wesley Ely
Jan 31, 2014·The New England Journal of Medicine·Michael C Reade, Simon Finfer
Jan 16, 2014·American Journal of Respiratory and Critical Care Medicine·Shruti B PatelJohn P Kress
Aug 21, 2013·Annals of the American Thoracic Society·Aluko A HopeJudith E Nelson
Mar 29, 2014·Der Nervenarzt·K Hüfner, B Sperner-Unterweger
Jan 29, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Shane O'HanlonDavid Meagher
Aug 31, 2012·Case Reports in Psychiatry·Evangelos PotolidisP M Kountra
Oct 5, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Benedikt Trabold, Thomas Metterlein
Nov 19, 2014·Journal of the American Medical Directors Association·Barbara J Messinger-RapportJohn E Morley
Jan 29, 2016·Journal of Critical Care·John MarshallJennifer P Stevens
Jan 23, 2016·Medizinische Klinik, Intensivmedizin und Notfallmedizin·A Kersten, S Reith
Jan 30, 2014·AORN Journal·Paula BrooksEileen Stuart-Shor
Jun 19, 2013·Medicina intensiva·E Celis-RodríguezUNKNOWN Federación Panamericana e Ibérica de Sociedades de Medicina Crítica y Terapia Intensiva
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·David J MeagherNiamh O'Regan
Apr 29, 2015·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Satoshi UedaYoshiro Okubo
Jan 19, 2016·International Psychogeriatrics·Yasuyuki OkumuraUNKNOWN DELIRIA-J Group
Mar 15, 2013·Journal of the American Medical Directors Association·Quratulain Syed, Barbara J Messinger-Rapport

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here