Efficacy and Safety of Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization for Hepatocellular Carcinomas Compared with Radiofrequency Ablation Alone: A Time-to-Event Meta-Analysis

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Xin WangShuixiang He

Abstract

To compare the efficacy and safety of combined radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE) with RFA alone for hepatocellular carcinomas (HCC). Randomized controlled trial (RCT) studies that compared the clinical or oncologic outcomes of combination therapy of TACE and RFA versus RFA for the treatment of HCC were identified through literature searches of electronic databases (Pubmed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, and Google Scholar). Hazard ratios (HRs) or odds ratios (ORs) with their corresponding 95% confidence interval (CI) were combined as the effective value to assess the summary effects. The strength of evidence was rated by the Grading of Recommendations Assessment, Development, and Evaluation system. Six RCTs with 534 patients were eligible for inclusion in this meta-analysis. The meta-analysis showed that the combination of TACE and RFA is associated with a significantly longer overall survival (HR = 0.62, 95% CI: 0.49-0.78, p < 0.001) and recurrence-free survival (HR = 0.55, 95% CI: 0.40-0.76, p < 0.001) in contrast with RFA monotherapy. The seemingly higher incidence of major complications in the combination group c...Continue Reading

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Citations

Mar 2, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Won ChangJoon Koo Han
May 7, 2019·Gut and Liver·UNKNOWN Korean Liver Cancer Association, UNKNOWN National Cancer Center
Jan 23, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·In Sun YoonHeung Kyu Ko
Sep 2, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Tae Won ChoiJoon Koo Han
Nov 29, 2017·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Marius SchwalbePascale Tinguely
Jul 5, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·UNKNOWN Korean Liver Cancer Association (KLCA), UNKNOWN National Cancer Center (NCC), Goyang, Korea
Dec 20, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yeon Hyeon Choe
Mar 21, 2020·Current Treatment Options in Oncology·Cathal O'LearyMichael C Soulen
Apr 25, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sae Hwan Lee
Dec 1, 2020·International Journal of Radiation Biology·Chai Hong RimHakyoung Kim
Nov 24, 2020·Therapeutic Advances in Medical Oncology·David PrinceJiansong Ji

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