Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review

Seminars in Arthritis and Rheumatism
Roy AltmanMathew Nicholls

Abstract

Hyaluronic acid (HA) is a commonly prescribed intra-articular (IA) therapy for knee osteoarthritis (OA). While a single series of IA-HA has been well studied, the efficacy and safety of repeated courses of IA-HA injection therapy in knee OA patients have not been evaluated as frequently. A literature search was conducted using MEDLINE, EMBASE and PubMed databases. The primary outcome measure was knee pain reduction after each treatment course and/or last reported follow-up visit. Secondary outcomes were treatment-related adverse events (AEs) and serious adverse events (SAEs). A total of 17 articles (7 RCTs and 10 cohort studies) met the pre-defined inclusion criteria. Of the RCTs, six were double-blind with two trials including open label extension studies, and one was single-blind. Studies ranged from investigating a single reinjection cycle to four repeat injection cycles. Eleven studies evaluated one reinjection, five studies evaluated ≥2 repeated courses of IA-HA, and one study allowed either one or two repeated courses. All studies reported pain reduction from baseline in the IA-HA treatment group throughout the initial treatment cycle, and either sustained or further reduced pain throughout the repeated courses of treatme...Continue Reading

Citations

Aug 20, 2019·Recent Patents on Drug Delivery & Formulation·Sergei V Jargin
Feb 23, 2020·The Journal of Bone and Joint Surgery. American Volume·C Thomas VangsnessMichael J Daley
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