Efficacy and safety of rh-endostatin (Endostar) combined with pemetrexed/cisplatin followed by rh-endostatin plus pemetrexed maintenance in non-small cell lung cancer: A retrospective comparison with standard chemotherapy

Thoracic Cancer
Shengyu ZhouYuankai Shi

Abstract

Recombinant human endostatin (rh-endostatin) plus standard chemotherapy in advanced non-small cell lung cancer (NSCLC) patients has shown improved efficacy; however, it is unclear whether it is effective and safe when added to pemetrexed/cisplatin and used as maintenance therapy. We retrospectively evaluated the data of untreated NSCLC patients administered rh-endostatin plus pemetrexed/cisplatin or pemetrexed/cisplatin. The primary endpoint was progression-free survival (PFS). Fifty-six and 39 patients received rh-endostatin plus pemetrexed/cisplatin and pemetrexed/cisplatin, and 34 and 29 underwent maintenance treatment, respectively. The median PFS was 10 months (95% confidence interval [CI] 5.85-14.15) in the rh-endostatin and 8.2 months (4.04-12.36) in the chemotherapy group, but the difference was not statistically significant (P = 0.13). In patients administered maintenance treatment, rh-endostatin plus pemetrexed was associated with prolonged PFS compared to single-agent pemetrexed when PFS was calculated from first dosing (13.7 [9.41-17.99] vs. 8.2 [4.16-12.24]; P = 0.032); however, PFS did not differ between the groups (hazard ratio 0.618; 95% CI 0.368-1.038; P = 0.069) after adjusting for clinical factors. No differe...Continue Reading

References

Nov 14, 1997·Nature Medicine·M SkobeN E Fusenig
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jan 8, 2003·Seminars in Oncology·Judah Folkman
Feb 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LomasR Ward
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H JohnsonFairooz Kabbinavar
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giorgio Vittorio ScagliottiDavid Gandara
Oct 16, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K N SyrigosG V Scagliotti
May 3, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Baohui HanXianqiao Jin
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Dec 19, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nasser H HannaUNKNOWN LUME-Lung 2 Study group
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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