Efficacy and Safety of Rivaroxaban in Patients with Venous Thromboembolism and Active Malignancy: A Single-Center Registry

The American Journal of Medicine
Dalene M Bott-KitslaarWaldemar E Wysokinski

Abstract

The purpose of this study is to evaluate the efficacy and safety of rivaroxaban in patients with venous thromboembolism and active malignancy, given the paucity of clinical data with the use of direct Xa inhibitors in this high-risk population. Consecutive patients treated with rivaroxaban for deep vein thrombosis or pulmonary embolism, enrolled into Mayo Thrombophilia Clinic Direct Oral Anticoagulants Registry between March 1, 2013, and April 30, 2015, were followed prospectively to evaluate the efficacy and safety of this therapy. Of the 404 venous thromboembolism patients in the registry, 296 received rivaroxaban and had at least 3 months of follow-up. Of these, 118 (40%) had active malignancy (51% female, mean age 66 ± 10 years) and 178 had no cancer (47% female, mean age 55 ± 15 years). The 3 most common cancer locations were genitourinary (23.6%), gastrointestinal (20.3%), and lung (13.5%). There was no difference in venous thromboembolism recurrence between the malignant (3.3%) and the nonmalignant (2.8%) venous thromboembolism groups (P = .533). Borderline higher rates for major bleeding (P = .06) and nonmajor clinically relevant bleeding (P = .08) were observed in patients with cancer. The "real world" effectiveness an...Continue Reading

Associated Clinical Trials

Apr 20, 2018·Waldemar E. Wysokinski

References

Jul 1, 1984·American Heart Journal·R F GillumT E Kottke
Jul 11, 2003·The New England Journal of Medicine·Agnes Y Y LeeUNKNOWN Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Veno
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Sep 27, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Steven R DeitcherUNKNOWN ONCENOX Investigators
Dec 6, 2006·The American Journal of Medicine·Russell D HullUNKNOWN LITE Trial Investigators
Feb 9, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert D McBaneJohn A Heit
May 15, 2010·Thrombosis Research·Javier Trujillo-SantosUNKNOWN RIETE Investigators
Dec 7, 2010·The New England Journal of Medicine·Rupert BauersachsSebastian Schellong
Mar 28, 2012·The New England Journal of Medicine·Harry R BüllerAnnelise Segers

❮ Previous
Next ❯

Citations

Apr 3, 2016·Disease-a-month : DM·Harry E FuentesJoseph A Caprini
Jan 27, 2017·Drug Discoveries & Therapeutics·Nikolaos S Salemis
Dec 29, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Bruno Soriano PignataroEduardo Ramacciotti
Jul 18, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Saeed K AlzghariJon D Herrington
Mar 16, 2018·Expert Review of Respiratory Medicine·Luke S Howard
Mar 29, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Kellie J WeddleParth J Patel
Aug 22, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Elizabeth R PritchardEleanor C Hobaugh
Nov 22, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Jessie R Signorelli, Arpita S Gandhi
Jan 13, 2018·VASA. Zeitschrift für Gefässkrankheiten·Minna Voigtlaender, Florian Langer
Jan 28, 2018·Journal of the American Heart Association·Konstantinos N Aronis, Elaine M Hylek
Mar 29, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Alexander T Cohen, Rupert Bauersachs
Feb 21, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Megan K PhelpsTzu-Fei Wang
Feb 6, 2018·American Journal of Hematology·Michael B StreiffAlok A Khorana
Oct 21, 2017·Journal of Thrombosis and Thrombolysis·Elaine XiangJohn Papadopoulos
Dec 1, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cristhiam M Rojas-Hernandez
Oct 27, 2018·World Journal of Gastrointestinal Oncology·Aikaterini MastorakiNikolaos Arkadopoulos
Dec 4, 2016·Hematology·Michael B Streiff
Dec 30, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Megan D NicklausJacob K Kettle
Jul 27, 2018·Research and Practice in Thrombosis and Haemostasis·Tzu-Fei WangDavid Garcia
Aug 20, 2019·Journal of Thrombosis and Thrombolysis·Damon E HoughtonWaldemar E Wysokinski
Feb 5, 2021·Journal of Thrombosis and Thrombolysis·Ahmed K PashaRobert McBane Ii
May 28, 2017·The American Journal of Cardiology·Eva S LaubeSimon Mantha
Feb 10, 2019·Mayo Clinic Proceedings·Dalene M Bott-KitslaarWaldemar E Wysokinski
Jun 2, 2021·Journal of Thrombosis and Haemostasis : JTH·Danielle T VlaznyRobert D McBane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
A BigaroniH Bounameaux
Thrombosis Research
Maria Gabriella SantamariaWarfarin Optimal Duration Italian Trial (WODIT) Investigators
© 2022 Meta ULC. All rights reserved