Efficacy and safety of ruxolitinib in the treatment of patients with myelofibrosis.

Future Oncology
Cecilia Arana YiSrdan Verstovsek

Abstract

The JAK1 and JAK2 inhibitor ruxolitinib has approved indications in myelofibrosis, a BCR-AB1-negative myeloproliferative neoplasm associated with progressive bone marrow fibrosis and shortened survival. In Phase III clinical studies, ruxolitinib provided rapid and durable improvement of myelofibrosis-related splenomegaly and symptoms irrespective of mutation status, and was associated with a survival advantage compared with placebo or best available therapy. Because of dose-dependent cytopenias, blood count monitoring and dose titration are important to optimize therapy. Specific precautions apply to the treatment of patients with or at risk of serious infections. Discontinuation of ruxolitinib generally leads to symptom return within 1 week. Ruxolitinib also is approved for treatment of patients with polycythemia vera who have had an inadequate response to or are intolerant of hydroxyurea.

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Citations

Oct 13, 2017·Hematology·Timothy DevosFleur Samantha Benghiat
Jan 16, 2019·Expert Opinion on Investigational Drugs·Jorge Ocampo-GarzaAntonella Tosti
Jun 26, 2020·British Journal of Haematology·Fiorenza BarracoHeinz Gisslinger
Dec 20, 2017·HemaSphere·Leonard Naymagon, John Mascarenhas
Dec 5, 2020·Hematology·Anand A Patel, Olatoyosi Odenike
Jan 26, 2021·Frontiers in Oncology·Cirino BottaFrancesco Mendicino
Jun 24, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Rieke SchröderJesús Duque-Afonso
Aug 8, 2021·International Journal of Molecular Sciences·Hsing-Ju Wu, Pei-Yi Chu

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Methods Mentioned

BETA
pharmacotherapy

Clinical Trials Mentioned

NCT02055781
NCT02101268
NCT01969838

Software Mentioned

International Prognostic Scoring Systems ( IPSS )
COMFORT

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