Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitors in East Asians with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
Lidan YangZhenmei An

Abstract

The aim of this study was to assess the efficacy and safety of sodium-glucose cotransporter 2 (SGLT2) inhibitors in East Asians with type 2 diabetes mellitus (T2DM). A literature search that focused primarily on the PubMed, Embase, and Cochrane library databases was performed. All randomized controlled trials (RCTs) which satisfied the inclusion and exculsion criteria were eligible to be included in the meta-analysis. Risk ratios (RRs) and weighted mean differences (WMDs) were used as statistical indicators for the analysis of dichotomous data and continuous outcomes, respectively. Pooled estimates were obtained using random-effects models in RevMan version 5.3.5. Thirty-three RCTs (8496 randomized patients) fulfilled the eligibility criteria for inclusion in the meta-analysis. The meta-analysis showed that, compared with the control group, the use of SGLT2 inhibitors improved both glycated hemoglobin (HbA1c) in patients (WMD - 0.73%; 95% confidence interval [CI] - 0.84, - 0.61) and the percentage of patients with HbA1c  < 7% (RR 2.33; 95% CI 1.74, 3.12); lowered both fasting plasma glucose (WMD - 28.47 mg/dl; 95% CI - 32.86, - 24.08) and postprandial glucose (WMD - 52.32 mg/dl; 95% CI - 67.67, - 39.96); reduced body weight (WM...Continue Reading

References

Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Apr 5, 2013·Annals of the New York Academy of Sciences·Ronald C W Ma, Juliana C N Chan
Apr 17, 2013·The Journal of Clinical Endocrinology and Metabolism·Elizabeth R SeaquistUNKNOWN Endocrine Society
Sep 13, 2013·Annals of Internal Medicine·Despoina VasilakouApostolos Tsapas
Sep 4, 2015·The New England Journal of Medicine·Andrew T Hattersley, Bernard Thorens
May 18, 2016·Journal of Diabetes Investigation·Yutaka SeinoDaisuke Yabe
Mar 2, 2017·JAMA : the Journal of the American Medical Association·Jane E B Reusch, JoAnn E Manson
May 29, 2018·Diabetes Research and Clinical Practice·Hyun Jeong JeonTae Keun Oh

❮ Previous
Next ❯

Citations

Sep 22, 2019·Journal of Diabetes Investigation·Yoshihito Fujita, Nobuya Inagaki
May 10, 2020·Diabetes, Obesity & Metabolism·Anat FisherUNKNOWN Canadian Network for Observational Drug Effect Studies (CNODES) Investigators

❮ Previous
Next ❯

Software Mentioned

RevMan
GraphPad Prism

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.