Efficacy and safety of sofosbuvir plus daclatasvir with or without ribavirin: large real-life results of patients with chronic hepatitis C genotype 4

Hepatology International
Adel Abdel-MoneimMohamed Ramadan

Abstract

Clinical studies evaluating the efficacy of daclatasvir (DCV) for treatment of chronic hepatitis C virus (HCV) genotype 4 (GT4) infection are scarce. This study aims to evaluate the efficacy and safety of DCV plus sofosbuvir (SOF) with or without ribavirin (RBV) for treatment of Egyptian patients infected with HCV GT4. Between April 2016 and March of 2017, a large cohort of 946 patients with chronic HCV GT4 was enrolled for completing the treatment. Patients were classified into two groups: group 1 (easy to treat) was treated with a dual therapy of SOF/DCV daily for 12 weeks and group 2 (difficult to treat) was treated with a triple therapy of SOF/DCV/RBV daily for 12 weeks. Efficacy and safety of the treatments were estimated, and baseline characters associated with sustained virological response at 12 weeks post-treatment (SVR12) were investigated. Among the patient's cohort, SVR12 was achieved by 94% (891/946) in the overall patients, by 95% (718/758) in the easy-to-treat group, and by 92% (173/188) in the difficult-to-treat group. The most common adverse events recorded were fatigue, headache, nausea, asthenia, and gastrointestinal troubles. No patient discontinued treatment due to severe adverse events. The findings from t...Continue Reading

Associated Clinical Trials

References

Oct 24, 2002·Journal of Clinical Gastroenterology·Hashem B El-Serag
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
May 26, 2010·Alimentary Pharmacology & Therapeutics·W AlazawiG R Foster
Dec 29, 2011·Antimicrobial Agents and Chemotherapy·Chunfu WangRobert A Fridell
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jeremie GuedjAlan S Perelson
Apr 24, 2013·The New England Journal of Medicine·Eric LawitzEdward J Gane
Jan 17, 2014·The New England Journal of Medicine·Mark S SulkowskiUNKNOWN AI444040 Study Group
Aug 3, 2014·Journal of Hepatology·Erin GowerHomie Razavi
Jan 24, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David R NelsonUNKNOWN ALLY-3 Study Team
Mar 15, 2015·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Manabu Amano, Hiroki Ishikawa
Jan 30, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincent LeroyAlexander J Thompson
Mar 5, 2016·CPT: Pharmacometrics & Systems Pharmacology·L S WuD Z D'Argenio
Jun 6, 2016·Journal of Hepatology·Audrey CoillyUNKNOWN ANRS C023 CUPILT study group
Jun 9, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Amr KandeelMaha Talaat
Jul 31, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Jordan J FeldJean-Michel Pawlotsky
Dec 25, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Kerstin HerzerStefan Zeuzem
May 11, 2018·Journal of Clinical and Experimental Hepatology·Asmaa M Abdel-AzizHisham Abdelhaleem

❮ Previous
Next ❯

Citations

May 23, 2019·Clinical Pharmacokinetics·Elise J SmoldersDavid M Burger
Sep 15, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN AASLD-IDSA HCV Guidance Panel
Nov 24, 2018·Virology Journal·Antonio Di BiagioGiovanni Cenderello
Oct 23, 2018·World Journal of Gastroenterology : WJG·Dalia OmranMohamed El Kassas
Aug 16, 2019·World Journal of Gastroenterology : WJG·Massimo Giuseppe ColomboSanjay Hadigal
Jul 12, 2018·Hepatology International·Tatsuo KandaMitsuhiko Moriyama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.