Efficacy and safety of solifenacin succinate in Korean patients with overactive bladder: a randomised, prospective, double-blind, multicentre study.

International Journal of Clinical Practice
M-S ChooJ G Lee

Abstract

We assessed the efficacy and safety of solifenacin compared with tolterodine for treatment of overactive bladder (OAB) in Korean patients. The study was randomised, double-blind, tolterodine-controlled trial in Korea. Patients had average frequency of >or= 8 voids per 24 h and episodes of urgency or urgency incontinence >or= 3 during 3-day voiding diary period. Patients were randomised to 12-week double-blind treatment with either tolterodine immediate release (IR) 2 mg twice daily (TOL4) or solifenacin 5 mg (SOL5) or 10 mg (SOL10) once daily. The outcome measure was mean change in daily micturition frequency, volume, daily frequency of urgency incontinence, urgency and nocturia from baseline to week 12. Quality of life was assessed using the King's Health Questionnaire. A total of 357 were randomised and 329 were evaluated for efficacy. All voiding parameters recorded in micturition diary improved after treatment in all three groups. Mean changes in volume voided were 19.30 ml (26.69%) in TOL4, 30.37 ml (25.89%) in SOL5 and 37.12 ml (33.36%) in SOL10 group (p = 0.03). Speed of onset of SOL10 efficacy on urgency incontinence was faster than that of SOL5 and TOL4. Quality of life improved in all three groups. Dry mouth was the m...Continue Reading

References

Jan 9, 1998·British Journal of Obstetrics and Gynaecology·C J KelleherS Salvatore
Apr 27, 2001·Mayo Clinic Proceedings·R A AppellUNKNOWN Overactive Bladder: Judging Effective Control and Treatment Study Group
Jul 18, 2002·Naunyn-Schmiedeberg's Archives of Pharmacology·Ken IkedaKazuo Honda
Feb 1, 2003·Urology·Paul AbramsUNKNOWN Standardisation Sub-Committee of the International Continence Society
Jun 19, 2007·European Urology·Christopher R ChappleUNKNOWN STAR study group

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Citations

Feb 9, 2012·International Urogynecology Journal·Deyi LuoHong Shen
Jun 27, 2013·Expert Opinion on Drug Safety·Gian Marco RosaClaudio Brunelli
Oct 25, 2013·Neurourology and Urodynamics·Véronique PhéEmmanuel Chartier-Kastler
Jan 2, 2018·Journal of Managed Care & Specialty Pharmacy·Ali B GoodsonBrian C Lund
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Priya MadhuvrataE Jean C Hay-Smith
Feb 20, 2018·Molecular Cancer·Chee-Seng TanRoss A Soo
May 4, 2015·Journal of Hematology & Oncology·Gaurav Goel, Weijing Sun
Nov 23, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·V Phé, X Gamé

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