Abstract
The allergological relevance of Ambrosia in Europe is growing but the efficacy of the injective immunotherapy for this allergen has been documented only in Northern America. We sought to study the safety and efficacy of injective immunotherapy in European patients sensitized to Ambrosia artemisiifolia. Thirty-two patients (18 M/14 F, mean age 36.78, range 23-60 years) suffering from rhinoconjunctivitis and/or asthma and sensitized to Ambrosia were enrolled and randomized in a double-blind, placebo-controlled (DBPC) study lasting 1 year. A maintenance dose corresponding to 7.2 microg of Amb a 1 was administered at 4-week intervals after the build-up. During the second and the third year, all patients were under active therapy in an open fashion. Symptom and medication scores, skin reactivity to Ambrosia (parallel line biological assay), and pollen counts were assessed throughout the trial. Twenty-three patients completed the trial. No severe adverse event was observed. During the DBPC phase, actively treated patients showed an improvement in asthmatic symptoms (P=0.02) and drug (P=0.0068) scores days with asthmatic symptoms (P=0.003), days with rhinitis symptoms (P=0.05), and days with intake of drugs (P=0.0058), as compared to ...Continue Reading
References
Nov 1, 1979·Clinical Allergy·W D BrightonE Henocq
Apr 1, 1991·The Journal of Allergy and Clinical Immunology·O IliopoulosR M Naclerio
Sep 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G HedlinN F Adkinson
Sep 1, 1989·The Journal of Allergy and Clinical Immunology·G HedlinN F Adkinson
Aug 1, 1989·The Journal of Allergy and Clinical Immunology·P S CreticosP S Norman
Jan 1, 1987·Immunogenetics·D G MarshM Roebber
Nov 1, 1984·Clinical Allergy·J CarreiraW D Brighton
Apr 1, 1980·The Journal of Allergy and Clinical Immunology·T E Van MetreM D Valentine
Aug 1, 1981·The Journal of Allergy and Clinical Immunology·S R HirschS H Cohen
Feb 22, 1996·The New England Journal of Medicine·P S CreticosJ T Li
Jan 30, 1997·The New England Journal of Medicine·N F AdkinsonB Wheeler
Jan 1, 1997·Allergy·S MartínC Cortés
Oct 6, 1997·The Journal of Allergy and Clinical Immunology·R M NaclerioP S Norman
Aug 5, 1998·Allergy·G D'AmatoS Bonini
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·J BousquetH J Malling
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·J Bousquet
Mar 22, 2002·Allergy·U BødtgerH-J Malling
Sep 10, 2002·International Archives of Allergy and Immunology·Robert MovérareLena Elfman
Oct 3, 2002·Allergy·R Asero
Citations
Dec 22, 2011·Clinical Reviews in Allergy & Immunology·Christopher Chang
Oct 29, 2010·Current Medical Research and Opinion·Linda Cox, Moises A Calderon
Jul 9, 2011·Immunology and Allergy Clinics of North America·Linda Cox, Dana Wallace
May 31, 2011·The Journal of Allergy and Clinical Immunology·Paolo Maria MatricardiAnnemie Narkus
Apr 10, 2007·The Journal of Allergy and Clinical Immunology·Giovanni PassalacquaUNKNOWN Global Allergy and Asthma European Network
Dec 15, 2006·The Journal of Allergy and Clinical Immunology·Ronald van Ree
Mar 26, 2008·Allergy·J BousquetUNKNOWN AllerGen
Jan 25, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Passalacqua, G W Canonica
Nov 27, 2014·International Forum of Allergy & Rhinology·Cemal CingiFezan Sahin
Jul 9, 2013·The Laryngoscope·Nkiruka ErekosimaSandra Y Lin
Jan 6, 2011·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Kimihiro Okubo, Minoru Gotoh
May 23, 2015·PloS One·Jeong Hwan ParkTae-Hun Kim
Apr 9, 2008·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Rauf TahamilerAhmet Dirican
May 12, 2017·Allergy·S DhamiA Sheikh
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M A CalderonS Durham
Aug 6, 2010·The Cochrane Database of Systematic Reviews·Michael J AbramsonJohn M Weiner
Jul 15, 2015·Asthma Research and Practice·Giovanni PassalacquaGiorgio Walter Canonica
Dec 8, 2020·The Journal of Allergy and Clinical Immunology·UNKNOWN Expert Panel Working Group of the National Heart, Lung, and Blood Institute (NHLBI) administered and coordinated National AsColin G Walsh
Jul 25, 2019·International Archives of Allergy and Immunology·Jinqiu LiChengbi Xu
Nov 1, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Bradley E ChippsJohn Oppenheimer