Efficacy and Safety of Switching from Insulin Glargine 100 U/mL to the Same Dose of Glargine 300 U/mL in Japanese Type 1 and 2 Diabetes Patients: A Retrospective Analysis

Internal Medicine
Shuhei NakanishiHideaki Kaneto

Abstract

Objective Insulin glargine [300 U/mL (Gla-300)] achieved better glycemic control and reduced the risk of hypoglycemia in comparison to glargine [100 U/mL; (Gla-100)] in phase 3 trials. This is the first study to retrospectively evaluate the efficacy and safety of Gla-300 in Japanese type 1 and 2 diabetes patients in a routine clinical setting. Methods We analyzed 20 type 1 diabetes patients and 62 type 2 diabetes patients who switched from Gla-100 to the same dose of Gla-300. Sixty type 2 diabetes patients who continued the use of Gla-100 during the study were included as controls. Results At three months after switching, the HbA1c levels were decreased in the patients with type 1 diabetes, but not to a significant extent. In the type 2 diabetes patients, the HbA1c levels were significantly decreased after switching (p<0.01). In contrast, there was no change in the HbA1c levels of the type 2 diabetes patients who continued the use of Gla-100 over the same period. The BMI values of the type 1 diabetes patients tended to decrease (p=0.06) and there was a significant decrease in the BMI values of the type 2 diabetes patients (p<0.05). There was no change in the BMI values of the type 2 diabetes patients who continued the use of Gl...Continue Reading

References

Jan 5, 2002·Diabetes Research and Clinical Practice·Takeshi KuzuyaUNKNOWN Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Oct 28, 2003·Diabetes Care·Matthew C RiddleUNKNOWN Insulin Glargine 4002 Study Investigators
Jan 6, 2010·Diabetes Research and Clinical Practice·Hiroshi SakuraYasuhiko Iwamoto
Jun 13, 2012·The New England Journal of Medicine·Hertzel C GersteinSalim Yusuf
Oct 19, 2010·Journal of Diabetes Investigation·Yutaka SeinoKohjiro Ueki
Aug 28, 2015·Journal of Diabetes Science and Technology·David KlonoffThomas Haak

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