PMID: 16522977Mar 9, 2006Paper

Efficacy and safety of tacrolimus ointment monotherapy in chinese children with atopic dermatitis

Skinmed
Chi Keung YeungHenry Hin Lee Chan

Abstract

To assess the efficacy and patients' tolerance of topical tacrolimus ointment for the treatment of atopic dermatitis in Chinese children during hot and humid seasons. Tacrolimus ointment at a concentration of 0.03% was applied for up to 4 weeks. Patients were assessed at weekly intervals for adverse events and efficacy. Thirty-four patients completed the study. Twenty-seven percent of patients showed greater than 75% improvement according to the investigators' Global Evaluation of Clinical Response from Week 1 onward. The mean patients' assessment of treatment effects and Eczema Area Severity Index decreased by 60% after treatment for 4 weeks (p<0.001), and the mean score for patients' assessment of pruritus decreased by 41% at Week 4 (p<0.001). Pruritus and burning sensation were the two main adverse events reported. The short-term monotherapy of childhood atopic dermatitis with tacrolimus ointment is well tolerated and effective during the hot and humid seasons in Hong Kong.

References

Sep 24, 1994·Lancet·H NakagawaS Harada
Jul 15, 1995·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·P A KellyR Venkataramanan
Jun 1, 1995·The British Journal of Dermatology·M S Lewis-Jones, A Y Finlay
Mar 1, 1995·The British Journal of Dermatology·J Berth-Jones, P E Hutchinson
May 1, 1994·Clinical and Experimental Dermatology·A Y Finlay, G K Khan
Sep 1, 1995·The British Journal of Dermatology·H AoyamaH Tagami
Feb 3, 1998·Journal of the American Academy of Dermatology·S AlaitiI Bekersky
Sep 18, 1998·The Journal of Investigative Dermatology·S ReitamoA I Lauerma
Dec 29, 1998·The New England Journal of Medicine·G Marone
Jul 20, 1999·Journal of the American Academy of Dermatology·J M Hanifin, S Chan
Jan 6, 2001·Journal of the American Academy of Dermatology·J M HanifinE Rafal
Jan 6, 2001·Journal of the American Academy of Dermatology·S KangJ M Hanifin
Jan 5, 2002·Seminars in Cutaneous Medicine and Surgery·I BekerskyI Lawrence
Jan 5, 2002·Seminars in Cutaneous Medicine and Surgery·J Bergman, M J Rico

❮ Previous
Next ❯

Citations

Dec 1, 2011·International Journal of Dermatology·Kyu-Han Kim, Takeshi Kono
Sep 11, 2013·The Cochrane Database of Systematic Reviews·Sherman GuHywel C Williams
Nov 24, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·P V ChernyshovUNKNOWN EADV Quality of Life Task Force

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Journal of the American Academy of Dermatology
M Shane ChapmanUS Tacrolimus Ointment Study Group
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
Qing ZhouLong-zhong Fan
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Jayanth SridharLinda Sternau
The Journal of Sports Medicine and Physical Fitness
O HueC Hertogh
© 2021 Meta ULC. All rights reserved