Efficacy and safety of tarcrolimus cream 0.1% in the treatment of vitiligo

International Journal of Dermatology
Ai-E XuLiang-Jun Lu

Abstract

Vitiligo is an acquired, pigmentary skin disorder which is disfiguring and difficult to treat. Phototherapy and application of topical corticosteroids are most commonly prescribed. However, these therapies are often not effective and use of corticosteroids on the face may lead to cutaneous atrophy, telangiectasia, and ocular complications. We sought to assess the efficacy of topical tacrolimus ointment in the treatment of vitiligo. A prospective pilot study was performed of 30 patients with vitiligo. Patients were treated with tacrolimus ointment for at least 4 months. Clinical responses were documented during clinic visits, and by pretacrolimus and post-tacrolimus photography. Twenty-five (83.3%) patients showed some repigmentation at the end of 4 months. Patients with vitiligo for more than 5 years also responded well to tacrolimus ointment. Repigmentation in active vitiligo was superior to that in stable vitiligo. 80% of patients with segmental vitiligo of the head and neck showed some response to tacrolimus, but there was no statistical significance between segmental and vulgaris vitiligo. The mean percentage of repigmentation on the head and neck was greater than that on the trunk and extremities. Four patients initially e...Continue Reading

References

May 20, 1998·Journal of the American Academy of Dermatology·S O Kovacs
Sep 18, 1998·The Journal of Investigative Dermatology·S ReitamoA I Lauerma
Jan 22, 2000·Journal of the American Academy of Dermatology·M D NjooW Westerhof
Jul 8, 2000·Pediatric Dermatology·S ChoJ H Hahm
Aug 5, 2000·The Journal of Pathology·D J TobinK U Schallreuter
Jun 22, 2002·Journal of the American Academy of Dermatology·Daniel Berg, Clark C Otley
May 21, 2003·Archives of Dermatology·Veronica LepeAntonio B Torres-Rubalcava
May 21, 2003·Archives of Dermatology·Heidi PlettenbergThomas Ruzicka
Nov 4, 2004·Journal of the American Academy of Dermatology·Nanette B SilverbergAmy S Paller
Mar 1, 2005·Drugs·Kresimir Kostovic, Aida Pasic

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Citations

Nov 20, 2013·Indian Journal of Dermatology·Salil Kumar PanjaSitesh Chandra Lahiri
Aug 16, 2011·Journal of the American Academy of Dermatology·Lesley M FelstenVesna Petronic-Rosic
Oct 1, 2013·International Journal of Dermatology·Cho-Rok Kim, Dong-Youn Lee
Nov 2, 2019·Journal of Cosmetic Dermatology·Nagwa E Abd-ElazimAyman M Mahran
Jan 22, 2013·International Journal of Dermatology·Russell Wong, Andrew N Lin
Oct 8, 2014·Experimental and Therapeutic Medicine·Martha Elena Garcia-MelendezRocío Ortiz-López
Mar 1, 2011·The Journal of Dermatology·Montree UdompataikulRungthiwa Siriwattanagate
Nov 5, 2014·The Australasian Journal of Dermatology·Norashikin ShamsudinMohd Hani Ahmad Fadzil
Sep 8, 2011·The Journal of Dermatology·Du JuanZhang Jianzhong

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