Efficacy and safety of targeting VEGFR drugs in treatment for advanced or metastatic gastric cancer: a systemic review and meta-analysis

Oncotarget
Duanrui LiuYunshan Wang

Abstract

The value of targeting VEGFR (vascular endothelial growth factor receptor) drugs has demonstrated encouraging anti-cancer activity in advanced solid tumors within current clinical trials. This study aimed to serve as the first systemic review to assess their safety and efficacy according to biochemical characteristics of targeting VEGFR drugs in gastric cancer. We analyzed eight clinical trials on targeting VEGFR drugs in gastric cancer. Results showed that targeting VEGFR drugs significantly improved overall survival (OS) [Hazard Ratio (HR) 0.69, 95% confidence interval (CI) (0.55, 0.83),P <0.001], progression free survival (PFS) [HR 0.50, 95% CI (0.34, 0.66),P <0.001], disease control rate (DCR) [Odds Ratio (OR) 3.83, 95% CI (2.39, 6.15),P <0.001] and significantly decreased the progressive disease rate(PDR)[OR 0.45, 95% CI (0.34, 0.59),P <0.001], but not objective response rate (ORR) [OR 1.46, 95% CI (0.93, 2.29),P= 0.098]. Further subgroup revealed that VEGFR antibody (VEGFR-Ab) drugs were superior to VEGFR tyrosine kinase inhibitor (VEGFR-TKI) drugs in terms of the OS, PFS and PDR. To determine the toxic effect of targeting VEGFR drugs, the relative risk of adverse events (grade ≥ 3) of special interest(AESIs) were estimat...Continue Reading

References

Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 27, 2005·Cancer Investigation·J Stuart SalmonJordan Berlin
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marcin Kowanetz, Napoleone Ferrara
Nov 14, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ferry A L M Eskens, Jaap Verweij
Jul 8, 2009·Nature Reviews. Clinical Oncology·Helen X Chen, Jessica N Cleck
Sep 9, 2009·Nature Reviews. Clinical Oncology·S Percy IvyBennett M Kaufman
May 13, 2010·Investigational New Drugs·Yung-Jue BangAlberto Sobrero
May 13, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M MoehlerUNKNOWN German Arbeitsgemeinschaft Internistische Onkologie (AIO)
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Roshan das NairNadina B Lincoln
May 11, 2012·Current Pharmaceutical Design·Cunlong ZhangYuyang Jiang
Apr 27, 2013·Molecular Cancer Therapeutics·Lotfi Abou-ElkacemWiltrud Lederle
Jun 4, 2013·Expert Opinion on Emerging Drugs·Geoffrey Y Ku, David H Ilson
Aug 7, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jin LiHao Yu
Oct 5, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Milind JavleIan Chau
Oct 17, 2014·World Journal of Gastroenterology : WJG·Keishiro AoyagiKazuo Shirouzu
Jun 7, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sandra J CasakRichard Pazdur
Sep 4, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Giandomenico RovielloFranco Roviello
Dec 2, 2015·Drug Design, Development and Therapy·Haijun Zhang
Feb 14, 2016·Investigational New Drugs·Gianluca TomaselloRodolfo Passalacqua
Aug 17, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lorenzo FornaroAlfredo Falcone
Feb 7, 2017·Cancer Investigation·Giandomenico RovielloDaniele Generali
Mar 6, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Daisuke Takahari

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