Efficacy and safety of the trastuzumab biosimilar candidate CT-P6

Future Oncology
Francisco J EstevaJustin Stebbing

Abstract

Trastuzumab is an anti-HER2 monoclonal antibody indicated for the treatment of HER2-overexpressing breast and gastric cancers. Despite its clinical efficacy, access to the biological drug can be limited due to its relatively high price, especially in low-income countries. CT-P6 (Herzuma®) is a biosimilar candidate of originator or 'reference' trastuzumab, which may offer an alternative, more cost-effective treatment option. This article reviews the unmet needs of patients eligible to receive reference trastuzumab and the potential place of a trastuzumab biosimilar within the market. The review also summarizes the available clinical evidence supporting the biosimilarity of CT-P6 and reference trastuzumab with respect to pharmacokinetics, efficacy, safety and immunogenicity.

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Citations

Nov 6, 2018·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Su Jung KimJi Young Kim
Sep 12, 2019·Expert Opinion on Biological Therapy·Chen FuFrancisco J Esteva
Jun 30, 2019·Expert Opinion on Biological Therapy·Bruna Migliavacca ZucchettiGiuseppe Curigliano
Jun 22, 2018·Future Oncology·Xavier PivotElsa Curtit
Dec 5, 2019·Therapeutic Advances in Medical Oncology·Emily M Miller, Lee S Schwartzberg

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NCT02665637
NCT02162667
NCT01901146
NCT02594761
NCT02472964
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