Efficacy and safety of topical cyclosporine A 0.05% in vernal keratoconjunctivitis

Singapore Medical Journal
Ozlem Eski Yücel, Nihal Demir Ulus

Abstract

While corticosteroids are an effective choice of treatment for severe vernal keratoconjunctivitis (VKC), their long-term use is restricted due to their side effects. This study was conducted to evaluate the efficacy and safety of topical cyclosporine A (CsA) 0.05% in the treatment of VKC. A total of 30 patients of VKC who were resistant to topical corticosteroids, antihistamines and mast cell stabilisers were treated with topical CsA 0.05%. Patients were evaluated at the 4th, 8th and 12th week after the initiation of therapy. The symptoms and signs observed before and after treatment were recorded and scored, and the scores for the symptoms and signs, the need for topical corticosteroid and the ocular side effects were evaluated. At baseline, the median value of the symptoms and signs scores were 10 (range 5-18) and 6 (range 2-13), respectively. At the 4th week of treatment with topical CsA 0.05%, the median value of the symptoms and signs scores were 3 (range 0-14) and 3 (range 0-8), respectively. The reduction observed in the symptoms and signs scores were statistically significant. The reduction in the need for corticosteroid was statistically significant by the 12th week of therapy. No significant side effects were recorded...Continue Reading

References

Nov 1, 1991·Ophthalmology·J H Bleik, K F Tabbara
Dec 15, 1990·American Journal of Ophthalmology·A G SecchiA Leonardi
Nov 1, 1986·Survey of Ophthalmology·R B Nussenblatt, A G Palestine
Feb 1, 1996·American Journal of Ophthalmology·A M el-AsrarV Desmet
Sep 25, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Neri PucciAlberto Vierucci
Sep 20, 2005·The British Journal of Ophthalmology·S Tatlipinar, E K Akpek
Mar 21, 2006·The British Journal of Ophthalmology·M DaniellH R Taylor
Jun 13, 2006·Clinical & Experimental Ophthalmology·Atsuki FukushimaHisayuki Ueno
Oct 4, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Laura SpadavecchiaLucio Armenio
Jan 17, 2007·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Adil Kiliç, Bülent Gürler
Sep 13, 2008·Acta Ophthalmologica·Sunil Kumar
Oct 21, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Riccardina TesseLucio Armenio
Oct 15, 2010·International Journal of Immunopathology and Pharmacology·N PucciE Novembre
Jun 8, 2013·Ophthalmology·Kelvin Ho-Nam WanAlvin L Young
Jan 21, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Pakit VichyanondAndrea Leonardi

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Citations

Apr 2, 2020·Therapeutic Advances in Ophthalmology·Sepehr Feizi, Amir A Azari
Nov 6, 2020·The Ocular Surface·Sepehr FeiziAhmad Kheirkhah
Aug 7, 2021·Pharmaceuticals·DeGaulle I Chigbu, Bisant A Labib
Jul 17, 2021·Current Opinion in Allergy and Clinical Immunology·Denise Wajnsztajn, Abraham Solomon
Aug 29, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mohamed Amin HeikalAhmed Adel Shebl

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