Efficacy and Safety of Topical Silymarin Versus Low Fluence 1064-nm Q Switched Nd:YAG Laser in the Treatment of Melasma: A Comparative Randomized Trial.

Lasers in Surgery and Medicine
Shady M A IbrahimWafaa M A F El-Gendy

Abstract

The management of melasma is challenging and requires multiple uses of available therapeutic options. To compare the short-term efficacy and safety of topical silymarin and low fluence 1064-nm Q-switched ND:YAG laser for treatment of melasma with dermoscopic follow-up. Fifty female patients with melasma were included in this study. They were randomly divided into two groups. Group A: 25 patients were treated with six sessions of low fluence Q switched ND:YAG 1064-nm laser, and group B: 25 patients were treated with topical silymarin cream 1.4% with a 3-month treatment duration. Patients were evaluated clinically by the modified melasma area and severity index (mMASI) score. Dermoscopic examinations were performed before and after the treatment sessions. The severity of melasma, as evaluated dermoscopically and clinically by mMASI score, was significantly reduced after treatment in all patients with no recorded side effects. There was no statistically significant difference between both studied groups regarding the change in mMASI score and dermoscopic assessment of the patients after the treatment sessions. Both low fluence Q switched ND:YAG 1064-nm laser and topical silymarin cream appear to be safe and effective modalities in...Continue Reading

References

Mar 20, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Penpun WattanakraiSasima Eimpunth
May 7, 2010·The Journal of Dermatological Treatment·Kee Suck SuhSang Tae Kim
Oct 4, 2012·The Journal of Dermatological Treatment·Ji Hoon SimJung Hoon Lee
Oct 4, 2012·BMC Dermatology·Tagreed Altaei
Oct 24, 2013·Cutaneous and Ocular Toxicology·Havva Yıldız SeçkinMehmet Sahin
Sep 4, 2014·Anais Brasileiros De Dermatologia·Ana Carolina HandelHélio Amante Miot
Nov 6, 2015·Indian Journal of Dermatology·Ravali YalamanchiliJayadev Betkerur
Jun 29, 2016·Journal of Cosmetic Dermatology·Hilal GokalpYasemin Oram
Dec 3, 2016·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Brian Tian
Jan 20, 2018·Indian Journal of Dermatology, Venereology and Leprology·Konchok DorjayMohammad Adil
Aug 28, 2018·Journal of Cosmetic Dermatology·Ahmad NofalShimaa Osman
Oct 4, 2018·Journal of Cosmetic Dermatology·Jae Eun ChoiYoung Chul Kye
Aug 16, 2019·Journal of Cutaneous and Aesthetic Surgery·Swapnil D Shah, Sanjeev J Aurangabadkar

❮ Previous
Next ❯

Citations

Sep 3, 2021·Lasers in Surgery and Medicine·Iwona MicekJustyna Gornowicz-Porowska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Dermatological Treatment
Kee Suck SuhSang Tae Kim
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Penpun WattanakraiSasima Eimpunth
Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology
Ahmed SalemAmin Amer
© 2021 Meta ULC. All rights reserved