Efficacy and Safety of Topical Timolol Eye Drops in the Treatment of Myopic Regression after Laser In Situ Keratomileusis: A Systematic Review and Meta-Analysis

Journal of Ophthalmology
Xiaochen WangQiang Xu

Abstract

Aims. The aim of this study was to assess the efficacy and safety of timolol in the treatment of myopic regression after laser in situ keratomileusis (LASIK). Methods. We searched MEDLINE, CENTRAL, EMBASE, China National Knowledge Infrastructure (CNKI), and Chinese Biological Medicine (CBM) from the inception to July 2015 for relevant randomized controlled trials that examined timolol therapy for myopic regression. The methodological quality of the studies included was assessed using the Revman 5.3 software. Results. We included six clinical trials involving 483 eyes in this review, including 246 eyes in treated group and 237 eyes in controlled group. We observed statistically significant improvements on the postoperative SE in the 3 months. However, the change of CCT was not statistically different between the control group and the experimental group. There were fewer cases of IOP, UDVA, and CDVA in treated group having significant difference from the controlled group. Conclusions. Topical timolol could be an effective treatment for reduction of myopic regression especially the spherical errors after myopic LASIK. Further RCTs with larger sample sizes for these trials are warranted to determine the efficacy and limitation for ...Continue Reading

References

Feb 19, 1987·The New England Journal of Medicine·H S SacksT C Chalmers
Jan 1, 1997·Journal of Cataract and Refractive Surgery·I G Pallikaris, D S Siganos
Apr 1, 1997·Journal of Cataract and Refractive Surgery·J J Pérez-SantonjaJ L Alió
Oct 3, 1998·Seminars in Ophthalmology·C P Lohmann, J L Güell
Jun 1, 2000·Journal of Cataract and Refractive Surgery·W A Lyle, G J Jin
Aug 8, 2001·Journal of Cataract and Refractive Surgery·R MagallanesN Robledo
Oct 2, 2001·Survey of Ophthalmology·S A Melki, D T Azar
Jul 6, 2002·Archives of Ophthalmology·Kazunori MiyataTetsuro Oshika
Feb 5, 2003·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Jean-François RoulandPalaniswamy Sunder Raj
Mar 9, 2004·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Qing PanShuang-hua Xin
Mar 20, 2004·Journal of Cataract and Refractive Surgery·Daniel J HuMichael A Rosenberg
Mar 31, 2004·Journal of Cataract and Refractive Surgery·Julie M AlbietzSuzanne G McLennan
Jun 21, 2006·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Hong QiYueguo Chen
Jul 27, 2007·Investigative Ophthalmology & Visual Science·Yun-I ChenTony Hsiu-Hsi Chen
Jul 1, 2010·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Hatem E El-AwadyMohamed A Gad

❮ Previous
Next ❯

Citations

Mar 23, 2019·Nanomedicine·Aseel Mahmood Ibrahim Al-MashahedahJagat Rakesh Kanwar
Mar 22, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yung-Hsin ChengCatherine Jui-Ling Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.