Efficacy and safety of trabeculectomy with mitomycin C for childhood glaucoma: a study of results with long-term follow-up.

Clinics
Jair GiampaniRemo Susanna

Abstract

To evaluate the safety and effectiveness of trabeculectomy with mitomycin C in the management of childhood glaucoma. The use of antifibrotic agents enhances the success of trabeculectomy performed in both adults and children. A retrospective chart review (1991-2001) of 114 patients (114 eyes) from 0-14 years of age with congenital or developmental glaucoma. These patients underwent trabeculectomy with mitomycin but had not been previously treated with any antifibrotic agent. The mean patient age was 57.36+/-51.14 months (range: 0.5-168 months). Treatment was considered successful in 63 eyes (55.26%), with a mean intraocular pressure of 12.11+/-3.98 mmHg. For patients categorized as successfully treated, the mean follow-up time was 61.16+/-26.13 months (range 12-113 months). A post-surgical intraocular pressure of <16 was observed in 47 eyes. The life-table success rates for intraocular pressure control at 24, 36, 48, and 60 months were 90.2%, 78.7%, 60.7% and 50.8%, respectively. The cumulative probability of failure was 40.8% at 12 months. Following surgery, endophthalmitis appeared in eight eyes (4.88%) after an average 36.96 months (range: 1.7-106 months). Other complications included expulsive hemorrhage, flat anterior cham...Continue Reading

Citations

Oct 10, 2015·BioMed Research International·Gianluca ScuderiLuca Scuderi
Nov 10, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lars ChoritzHagen Thieme
May 28, 2011·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T Klink, F Grehn
Feb 1, 2018·Journal of Pediatric Ophthalmology and Strabismus·Nader H Bayoumi
Jun 1, 2014·Journal of Pediatric Ophthalmology and Strabismus·Sharaf KhanNeelakshi Bhagat
Dec 22, 2016·Journal of Glaucoma·Kateki VinodPaul A Sidoti
Dec 19, 2020·Journal of Glaucoma·Sam P GurneyManoj V Parulekar
May 13, 2021·Journal of Glaucoma·Veronique Promelle, Christopher J Lyons
Dec 6, 2011·Survey of Ophthalmology·M Reza RazeghinejadGeorge L Spaeth
Dec 21, 2021·Journal of Pediatric Ophthalmology and Strabismus·Sidra JabeenNaima Zaheer

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