EFFICACY AND SAFETY OF TREATMENT OPTIONS FOR VITREOMACULAR TRACTION: A Case Series and Meta-Analysis

Retina
Gina YuJorge G Arroyo

Abstract

To evaluate treatment options for vitreomacular traction (VMT). A retrospective, consecutive case series and a literature search with Boolean search logic. A random-effects meta-analysis was conducted to combine the rates of VMT resolution per treatment. Patients from studies analyzed were placed into cohorts based on the treatment received. Zero of 10 control, 3 of 7 intravitreal ocriplasmin (IVO, P = 0.10), 7 of 8 intravitreal expansile gas (pneumatic vitreolysis, PV, P < 0.01), and 10 of 10 pars plana vitrectomy (P < 0.01)-treated eyes experienced VMT release (VMTr) at Day 28. No patients developed retinal tears or detachment. One PV-treated (12.5%) eye developed a macular hole. Meta-analysis: Twenty-three of 131 prospective or retrospective and consecutive articles were included. Sixty-three eyes were treated with PV, 726 eyes were treated with intravitreal ocriplasmin, and 253 eyes were characterized as the control group (saline injection). The weighted rate of VMT resolution for the control group was 0.09 (95% confidence interval [CI]: 0.06-0.13), PV was 0.84 (95% CI: 0.76-0.92), and intravitreal ocriplasmin was 0.26 (95% CI: 0.23-0.29). Our analysis found that PV releases VMT in most patients and suggest that PV may be a...Continue Reading

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Citations

Aug 31, 2016·International Ophthalmology Clinics·Steven J Ryder, Justin H Townsend
Sep 1, 2017·Acta Ophthalmologica·James E NeffendorfTimothy L Jackson
Nov 8, 2017·Current Eye Research·Dario H VasquezArturo Santos
Oct 28, 2020·Ophthalmology and Therapy·Andreas KatsanosMaria Stefaniotou
Apr 27, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Mali OkadaJonathan Yeoh
May 23, 2021·Acta Ophthalmologica·Wen-Fei ZhangYou-Xin Chen
Jan 1, 2017·Ophthalmology Retina·Jennifer I LimUNKNOWN Macula Society Ocriplasmin for Vitreomacular Traction Study Group

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