PMID: 7032852Jan 1, 1982Paper

Efficacy and safety of triamcinolone acetonide aerosol in chronic asthma. Results of a multicenter, short-term controlled and long-term open study

Chest
I L BernsteinC J Falliers

Abstract

Triamcinolone acetonide aerosol (TAA) and a placebo aerosol were compared in a six-week, double-blind multicenter study. Ninety-six steroid-independent asthmatic patients were randomized into two parallel groups. Each patient was evaluated weekly. After four weeks of treatment, those patients treated with TAA showed highly significant (P less than 0.001) improvement from baseline in pulmonary function tests (FEV1, FVC, and FEF25-75%) and in asthmatic symptoms, whereas no significant improvement was observed in those patients who received placebo aerosol. In the TAA-treated patients, 78 percent were rated wtih an excellent or good response, compared with 24 percent in the placebo patients. During the subsequent one-week washout period, mean pulmonary function test values of the TAA-treated group were significantly reduced (P less than 0.0001). Eighty-eight patients continued into the one-year, open-label phase of the study. Highly significant (P less than 0.001) improvement from baseline was observed in pulmonary function tests and in asthmatic symptoms at each bimonthly evaluation during the 12-month segment. Mean plasma-cortisol level changes were not statistically significant. At the end of the long-term study, the performanc...Continue Reading

Citations

May 1, 1992·Journal of Clinical Pharmacology·B A ZabornyJ A Ziemniak
Feb 6, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Seth R SchwartzMilesh M Patel
Oct 29, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·K JacobsonT Uryniak
Jun 3, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J W RamsdellD Banerji
Jan 10, 1993·The New England Journal of Medicine·E R McFadden, I A Gilbert
Nov 3, 1998·The Journal of Allergy and Clinical Immunology·H A Boushey
Jan 1, 1982·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C J Falliers, A J Petraco
Jan 1, 1994·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M J Welch
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C J Falliers
Oct 1, 1987·Drug Intelligence & Clinical Pharmacy·C E Johnson
Nov 1, 1984·Pharmacotherapy·C S Tse, I L Bernstein

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