Efficacy and safety of two treatment algorithms in bipolar depression consisting of a combination of lithium, lamotrigine or placebo and paroxetine

Acta Psychiatrica Scandinavica
Marc L M van der LoosLamLit Study Group

Abstract

In a previous paper, we reported about the efficacy of the addition of lamotrigine to lithium in patients with bipolar depression. In the second phase of this study paroxetine was added to ongoing treatment in non-responders. Bipolar depressed patients (n = 124) treated with lithium were randomized to addition of lamotrigine or placebo. In non-responders after 8 weeks, paroxetine 20 mg was added for another 8 weeks to ongoing treatment. After 8 weeks the improvement in patients treated with lamotrigine vs. patients treated with placebo was significant. After addition of paroxetine this difference disappeared as a result of greater further improvement in the non-responders to placebo. Addition of lamotrigine to lithium was found effective in bipolar depressed patients. Further addition of paroxetine in non-responders to lithium plus lamotrigine did not appear to provide additional benefit, while it appeared to do so in non-responders to lithium plus placebo.

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Citations

May 25, 2012·European Archives of Psychiatry and Clinical Neuroscience·Konstantinos N FountoulakisEduard Vieta
Oct 16, 2012·Current Psychiatry Reports·Michelle M Sidor, Glenda M MacQueen
Feb 10, 2012·Depression Research and Treatment·Ben H Amit, Abraham Weizman
Nov 13, 2013·Bipolar Disorders·Søren Dinesen ØstergaardJimmi Nielsen
Jun 1, 2011·Annals of Medicine·Eduard Vieta, Francesc Colom
Feb 23, 2013·The International Journal of Neuropsychopharmacology·Gustavo H VázquezRoss J Baldessarini
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Aug 19, 2014·Expert Review of Neurotherapeutics·Genevieve Curran, Arun Ravindran
Dec 6, 2019·The International Journal of Neuropsychopharmacology·Konstantinos N FountoulakisHans Jurgen Moeller

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