Efficacy and safety of US-guided thermal ablation for primary hyperparathyroidism: a systematic review and meta-analysis

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Jieyi YeBaoxian Liu

Abstract

Purpose: To summarize the published literature on thermal ablation for primary hyperparathyroidism (PHPT) and to evaluate the effectiveness and safety of thermal ablation as a novel treatment strategy.Materials and methods: Two authors carried out the literature search using four databases independently, including PubMed, Embase, Cochrane, and Web of Science. The meta-analysis included prospective and retrospective data that compared post-ablative outcomes to pre-ablative values. The primary outcomes were parathyroid hormone (PTH), serum calcium and volume of the parathyroid gland (VPG).Results: From the 184 original articles, five studies (4 retrospective studies and 1 prospective study) examining 84 patients met the inclusion criteria. The meta-analysis showed significant reduction of PTH at 3 (standardized mean difference (SMD) =  -1.09, 95% confidence index (CI) =  -1.42 to -0.76, p < 0.001) and 6 months (SMD =  -1.13, 95% CI =  -1.46 to -0.80, p < 0.001) after thermal ablation. Serum calcium level was significantly reduced at 3 (mean difference (MD) =  -0.31, 95% CI =  -0.50 to -0.12, p  =  0.001) and 6 months (MD =  -0.31, 95% CI =  -0.46 to -0.17, p < 0.001) after thermal ablation. There was no significant difference bet...Continue Reading

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Citations

Apr 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Ying WeiMing-An Yu
Jul 27, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Xinyang LiYukun Luo

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