Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis

Multidisciplinary Respiratory Medicine
Paola RoglianiMaria Gabriella Matera

Abstract

Oral methylxanthines are effective drugs for the treatment of chronic obstructive respiratory disorders. The novel methylxanthine doxofylline, that has bronchodilator and anti-inflammatory activities, is not affected by the major drawback of theophylline. Nowadays large-scale quantitative synthesis comparing the efficacy and safety profile of doxofylline vs. theophylline in the treatment of asthma is still lacking. Therefore, we performed a quantitative synthesis to compare the efficacy/safety profile of doxofylline and theophylline in asthma. A pairwise and network meta-analyses were performed to assess the impact of doxofylline vs. theophylline and placebo on the change in asthma events, risk of adverse events (AEs), forced expiratory volume in 1 s (FEV1), and salbutamol use. Data obtained from 696 asthmatic patients were extracted from 4 randomized controlled trials published between 2015 and 2018. Doxofylline was significantly (P < 0.05) more effective than theophylline in reducing the daily asthma events (mean difference - 0.14, 95%CI -0.27 - 0.00) and risk of AEs (relative risk 0.76, 95%CI 0.59-0.99). Doxofylline was as effective as theophylline in improving FEV1, and a trend of superiority (P = 0.058) was detected for do...Continue Reading

References

Oct 3, 2006·Journal of the American College of Cardiology·Sripal Bangalore, Franz H Messerli
Jun 19, 2007·BMC Medical Informatics and Decision Making·Connie SchardtPaul Fontelo
Apr 13, 2010·Pulmonary Pharmacology & Therapeutics·Clive P Page
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Jun 29, 2011·BMC Medicine·Tianjing LiUNKNOWN Ad Hoc Network Meta-analysis Methods Meeting Working Group
Aug 16, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Jan 5, 2014·American Journal of Respiratory and Critical Care Medicine·Paul W JonesJadwiga A Wedzicha
Dec 1, 2012·Research Synthesis Methods·Gert van ValkenhoefNicky J Welton
Nov 16, 2016·Handbook of Experimental Pharmacology·D Spina, C P Page
Dec 15, 2016·Systematic Reviews·Hugo PedderSofia Dias
Jan 18, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Luigino CalzettaMaria Gabriella Matera
Feb 17, 2017·Therapeutic Advances in Drug Safety·Mario CazzolaMaria Gabriella Matera
Mar 10, 2017·Expert Review of Pharmacoeconomics & Outcomes Research·F S MenniniA P Caputi
Sep 16, 2017·Lancet·Ian D PavordAndy Bush
Dec 20, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Maria Gabriella MateraMario Cazzola
May 1, 2018·Pulmonary Pharmacology & Therapeutics·Mario CazzolaMaria Gabriella Matera
May 4, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Mario CazzolaMaria Gabriella Matera
May 22, 2018·European Journal of Pharmacology·Maria Gabriella MateraBarbara Rinaldi

❮ Previous
Next ❯

Citations

Feb 23, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiaohua ZhaoLing Yang
Feb 26, 2020·Respiratory Medicine·Mario Cazzola, Maria Gabriella Matera

❮ Previous
Next ❯

Clinical Trials Mentioned

ISRCTN65297911
ISRCTN22374987

Software Mentioned

GeMTC
DECiMAL
SUCRA
PRISMA
OpenMetaAnalyst
GraphPad Prism
GRADEpro GDT

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.