PMID: 8968295Jan 1, 1996Paper

Efficacy and side effects of beta 2-agonists by inhaled route in acute asthma in children: comparison of salbutamol, terbutaline, and fenoterol

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
D M ScalabrinC K Naspitz

Abstract

Thirty-seven separate episodes of acute bronchial asthma were studied in 21 asthmatic children. The bronchodilator, cardiovascular, and tremorigenic responses following administration of salbutamol (SAL), terbutaline (TER) and fenoterol (FEN) by closed-port intermittent nebulization were compared for a period of 8 hr. SAL was used at the maximum dose recommended by the manufacturer and TER and FEN at the average doses commonly used in children. Eleven acute attacks were treated with SAL, 12 with TER, and 14 with FEN. Pulmonary function was evaluated by clinical assessment and by the spirometric indices FEV1 and FEF25-75. Tremor was objectively measured, as well as heart rate (HR), respiratory rate, and blood pressure. The onset of bronchodilating effect occurred at 5 min for all three drugs and there were no differences in intensity and duration of bronchodilation between drugs. All three drugs caused rapid onset of tremor (5 min) and this tended to be more intense with SAL. There was a slight decrease in HR in the TER group, whereas SAL and FEN caused increase in HR, with mean values significantly greater than in the TER group from 5 to 30 min after drug administration. Our results indicate that the three short-acting beta 2-a...Continue Reading

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Citations

Aug 31, 2011·Revista da Associação Médica Brasileira·UNKNOWN Brazilian Society of PediatricsSandra E Vieira
Jul 23, 2013·Journal of Pediatric Psychology·Jonathan M FeldmanDenise Serebrisky
Nov 30, 2005·Psychosomatic Medicine·Jonathan M FeldmanPaul M Lehrer
Jun 9, 2009·Seminars in Pediatric Neurology·Stephanie Keller, Leon S Dure
Aug 1, 2008·Journal of Anxiety Disorders·Jonathan M FeldmanPaul M Lehrer
Aug 19, 2007·Journal of Anxiety Disorders·Paul M LehrerRuss Reynolds
Sep 2, 2000·Annals of Emergency Medicine·R K Cydulka
Sep 16, 2003·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Doaa HabashyGary J Browne

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