PMID: 776314Jun 1, 1976

Efficacy and side effects of nitrazepam and thioridazine as sleeping aids in psychogeriatric in-patients

The British Journal of Psychiatry : the Journal of Mental Science
M Linnoila, M Viukari


The efficacy and side effects of 10 mg of nitrazepam and 25 mg of thioridazine as sleeping aids were measured in 20 psychogeriatric in-patients during the 14th night and morning of drug administration. The trial used a double blind, cross-over design. The effect of nitrazepam was slightly faster than that of thioridazine. After thioridazine, but not after nitrazepam, the patients slept significantly longer than after placebo. Nitrazepam, but not thioridazine, significantly impaired patients' abilities to move and to conduct everyday activities. It is concluded that thioridazine is a suitable sleeping aid for psychogeriatric patients, but that nitrazepam should be avoided.


Jan 1, 1972·Gerontologia Clinica·C P Silver
Mar 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·I Haider
Dec 1, 1970·The British Journal of Psychiatry : the Journal of Mental Science·H MorganC R Joyce
Oct 1, 1972·The American Journal of Psychiatry·G E Crane
Jan 1, 1964·Gerontologia Clinica·B ISAACS, F A WALKEY


May 8, 1979·Psychopharmacology·L KangasJ Salminen
Apr 17, 1979·European Journal of Clinical Pharmacology·L KangasE Syvälahti
Jun 25, 1999·Progress in Neurobiology·P GareriG De Sarro
Mar 1, 1994·Journal of Sleep Research·K Morgan
May 1, 1986·Journal of the American Geriatrics Society·S C Risse, R Barnes
Jan 18, 2003·Sleep Medicine Reviews·Susan M. McCurryMichael V. Vitiello
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Nov 1, 2001·The Cochrane Database of Systematic Reviews·V KirchnerR J Harvey
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