Efficacy and survival of biologic agents in psoriasis: a practical real-life 12-year experience in a French dermatology department

The Journal of Dermatological Treatment
Hélène RocheFrançois Aubin

Abstract

Background: Drug survival in a real-life setting is critical to long-term use of biologics for psoriasis. Objective: We describe our 12-year experience with biologics in psoriasis patients. Patients and Methods: All patients treated with biologics including infliximab, adalimumab (ADA), etanercept (ETA), and ustekinumab (UST) for psoriasis vulgaris between January 2005 and December 2016 were retrospectively analyzed. Results: In total, 545 treatment series were administered to 269 patients, including 211 treatment series with ADA, 135 with ETA, 77 with infliximab, and 122 with UST. ADA and ETA were initiated most often as first-line therapy; 65.3% of treatment sequences were discontinued. UST had the highest drug survival. The major reason for treatment termination was a loss of efficacy (44.9%). Definitive discontinuation increased with the number of biologic therapy sequences. Limitations: Subjects were not randomized to the different treatments. Conclusions: In a long-term real-life setting, drug survival of UST is better than that of TNF-a inhibitors for both biologic-naive and biologic-experienced patients with psoriasis.

References

Aug 1, 2012·Journal of the American Academy of Dermatology·Howa YeungJoel M Gelfand
Feb 28, 2013·The Journal of Dermatological Treatment·Machaon BonafedeShravanthi R Gandra
Oct 15, 2013·The British Journal of Dermatology·L HsuA W Armstrong
May 21, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·J-M CarrascosaJ C Prinz
Oct 18, 2014·Acta Dermato-venereologica·Laure PhilippeFrançois Aubin
Jan 12, 2017·Dermatology : International Journal for Clinical and Investigative Dermatology·Julia-Tatjana MaulAlexander A Navarini
May 2, 2017·The Journal of Investigative Dermatology·Zarif K Jabbar-LopezCatherine H Smith

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Citations

Feb 10, 2019·The British Journal of Dermatology·L MerciecaC E M Griffiths
Jun 10, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·L S van der SchootE M G J de Jong
Nov 5, 2019·The Journal of Dermatological Treatment·Nishadh Sutaria, Shiu-Chung Au

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