Efficacy and tolerability of 2-L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate: a randomized controlled trial

International Journal of Colorectal Disease
Seung In SeoWoon Geon Shin

Abstract

Previous studies comparing 2-L polyethylene glycol (PEG)-based solution with ascorbic acid (PEG/Asc) with sodium picosulfate/magnesium citrate (SP/MC) drew inconclusive results. This study aimed to compare a 2-L-PEG/Asc with SP/MC by split method in bowel cleansing efficacy, tolerability, and safety and to identify factors influencing inadequate bowel preparation. We performed a prospective randomized, endoscopist-blinded, single-center, controlled trial. The Aronchick scale and Ottawa bowel preparation scale (OBPS) were used to evaluate the bowel cleansing efficacy, and patients' tolerability and preferences were assessed by questionnaire. In total, 223 patients were randomized to receive 2-L-PEG/Asc (n = 109) or SP/MC (n = 114). There was no significant difference in overall bowel cleansing efficacy between the two groups; however, when analyzing by individual segment, mean bowel cleansing efficacy of right colon showed a trend in favor of SP/MC group than in PEG/Asc group (OBPS; 1.55 ± 0.66 vs. 1.74 ± 0.88, P = 0.08). Furthermore, SP/MC was better tolerated than PEG/Asc based on ease of consumption and preference to receive the agents again in the future. Total adverse events were significantly lower in SP/MC group than PEG/...Continue Reading

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Citations

Feb 27, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Soo-Young Na, Won Moon
May 11, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Daisuke YamaguchiMotohiro Esaki
May 16, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Milou L M van RiswijkPeter D Siersema

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