Abstract
This study was aimed to evaluate the efficacy and tolerability of bisoprolol, in Indian patients diagnosed with stage I essential hypertension as first-line drug. This was an open-label, phase IV, multicentric prospective study. 239 outpatient centres across India. After ethical approval, patients who were willing to sign informed consent, who are newly diagnosed with JNC VII stage I essential hypertension (systolic blood pressure 140-159 mm Hg or diastolic blood pressure 90-99 mm Hg) and who are prescribed bisoprolol were enrolled in the study. Patients with significant organ disease or complications, women of childbearing age refusing reliable contraceptive method, patients with known contraindications (like symptomatic bradycardia, significant atrioventricular blockade, sick sinus syndrome) and patients with known hypersensitivity reactions to bisoprolol and unwilling patients were excluded. PRIMARY AND SECONDARY OUTCOMES MEASURES: The primary outcome measure was percentage of patients achieving blood pressure (BP) ≤140/90 mm Hg at the end of 12 weeks, while multiple secondary outcome measures were assessed. Of 2418 patients screened, 2161 patients were recruited (66.64% men, mean age 51.7±9.8 years, smokers 19.19%) and 2...Continue Reading
References
Jan 1, 1986·Journal of Cardiovascular Pharmacology·H U JankaH Mehnert
Jan 1, 1987·European Journal of Clinical Pharmacology·G Frithz, L Weiner
Apr 16, 1986·European Journal of Pharmacology·H J SchliepG Haeusler
Aug 1, 1981·Circulation Research·A S ManalanA M Watanabe
Jul 10, 1993·BMJ : British Medical Journal·R JacksonT Maling
Feb 1, 1993·The American Journal of Medicine·J M NeutelM A Weber
Apr 1, 1993·The New England Journal of Medicine·B J MatersonJ Gottdiener
May 24, 1997·Lancet·C J Murray, A D Lopez
Apr 28, 1999·Journal of Cardiovascular Pharmacology·R FogariP Lusardi
Nov 28, 2001·Circulation·S YusufS Anand
Jan 17, 2002·The New England Journal of Medicine·R S VasanD Levy
May 21, 2003·Hypertension·Claude LenfantUNKNOWN Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Jun 28, 2003·BMJ : British Medical Journal·M R LawR E Jordan
Jan 20, 2004·Journal of Human Hypertension·R Gupta
Mar 30, 2006·Diabetologia·V MohanM Datta
Aug 22, 2006·Lancet·Thomas A GazianoMilton C Weinstein
Oct 20, 2009·Journal of Hypertension·Giuseppe ManciaUNKNOWN European Society of Hypertension
Mar 18, 2011·Current Medical Research and Opinion·B TomlinsonF Follath
Aug 17, 2011·Indian Journal of Pharmacology·V A BadarM M Hardas
Citations
Oct 27, 2016·Clinical Pharmacology in Drug Development·Ulrike Gottwald-HostalekSteven Hildemann
May 21, 2020·Chinese Medical Journal·Yun-Dai ChenTae-Hoon Kim
Sep 16, 2021·Cardiovascular Drugs and Therapy·E DudinskayaV Larina