Efficacy and tolerability of admixing 0.3% lidocaine with Dermicol-P35 27G for the treatment of nasolabial folds

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Susan H Weinkle

Abstract

Dermicol-P35 27G, an advanced collagen dermal filler, is effective for nasolabial fold (NLF) correction. To compare the efficacy and tolerance of Dermicol-P35 27G premixed with lidocaine with that of Dermicol-P35 27G injected after topical anesthesia for NLF correction. In a split-face protocol, 10 patients were injected with Dermicol-P35 27G/topical anest:esia or Dermicol-P35 27G/0.3% lidocaine. Patients were monitored for adverse events and for pain using the Thermometer Pain Scale (TPS) and a visual analog scale (VAS). Efficacy was measured using the Modified Fitzpatrick Wrinkle Scale and the Global Aesthetic Improvement Scale. Patients experienced significantly less pain with Dermicol-P35 27G/0.3% lidocaine than with Dermicol-P35 27G/topical anesthesia (mean clinician-assessed TPS scores +/- standard deviation: 2.0 +/- 0.8 and 5.2 +/- 2.1, respectively, p<.001). Patients reported less discomfort with Dermicol-P35 27G/0.3% lidocaine than with Dermicol-P35 27G/topical anesthesia (mean VAS scores: 2.0 +/- 1.0 and 6.3 +/- 2.0, respectively, p<.001; TPS scores: 2.3 +/- 0.6 and 5.4 +/- 1.2, respectively, p<.001). Both treatments yielded similar efficacy scores and were well tolerated. Adverse events were mild. Dermicol-P35 27G/0....Continue Reading

References

Sep 1, 1990·Journal of Biomedical Materials Research·L L Huang-LeeM E Nimni
Jan 1, 1985·Aesthetic Plastic Surgery·L S CoopermanB B Pharriss
Apr 1, 1987·Plastic and Reconstructive Surgery·F DeLustroL Ellingsworth
Apr 9, 2005·Clinics in Plastic Surgery·Rhoda S Narins, Paul H Bowman
Jan 31, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Claudio DeLorenziArthur Swift
Sep 1, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sandu PitaruNaftali Savion
Dec 22, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·David ShoshaniArie Goldlust
Dec 22, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rhoda S NarinsSandi McIntyre
Dec 21, 2007·Dermatologic Therapy·Mariano Busso, David Applebaum
Jul 2, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mariano Busso, Robert Voigts
Jul 2, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rhoda S NarinsStacy R Smith
Jul 2, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·David ShoshaniDavid J Narins

❮ Previous
Next ❯

Citations

Sep 4, 2012·Journal of Cosmetic Dermatology·Sabrina FabiIsabella Guiha
Nov 2, 2016·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Young-Jun ChoiWon-Serk Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Rhoda S NarinsCarl S Hornfeldt
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Ming-yong YangQiang Li
© 2021 Meta ULC. All rights reserved