Efficacy and tolerability of different brands of intravenous immunoglobulin in the maintenance treatment of chronic immune-mediated neuropathies

Journal of the Peripheral Nervous System : JPNS
Francesca GalliaEduardo Nobile-Orazio

Abstract

High-dose intravenous immunoglobulin (IVIg) is effective in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN). Not all brands of IVIg are however licensed for these neuropathies. We reviewed six patients with CIDP and seven with MMN treated with maintenance therapy with IVIg from 2009 to 2013. In all patients, we measured the Medical Research Council (MRC) and Overall Neuropathy Limitation Scale (ONLS) scores before each infusion, registered the monthly dose and brand of IVIg, and recorded adverse events. Patients were treated for 25-60 months (mean 49 months) alternating different brands of IVIg including IgVena, Gammagard, Kiovig, and Flebogamma. Minor and transient side effects were equally observed with each brand. No difference in the MRC or ONLS scores was observed in relation to the brand of IVIg used. Chronic maintenance treatment with IVIg in patients with MMN and CIDP was not associated with a different tolerability or efficacy despite the use of different brands of IVIg.

Citations

Jun 10, 2017·Expert Review of Neurotherapeutics·Eduardo Nobile-OrazioMariangela Bianco
Nov 2, 2017·Journal of the Peripheral Nervous System : JPNS·Krista KuitwaardPieter A van Doorn
Aug 14, 2018·Current Opinion in Neurology·Katie BeadonJean-Marc Léger

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