PMID: 8595641Sep 1, 1995Paper

Efficacy and tolerability of gabapentin in clinical practice

Clinical Therapeutics
G L Morris

Abstract

The efficacy and tolerability of gabapentin therapy for seizures in patients in clinical practice were retrospectively evaluated. Demographics, seizure type and history, prior anticonvulsant therapy, concomitant anticonvulsant medications, gabapentin dosing, side effects, seizure response, and tolerability data were obtained from 100 consecutive clinical practice patients (47 men and 53 women) treated with gabapentin. All patients had been previously treated with a mean of 2.9 anticonvulsant drugs and were currently taking a mean of 1.75 anticonvulsant drugs. Seventy-two patients experienced a greater than 50% reduction in seizures, and 23 of these patients experienced a greater than 75% reduction; 57 patients continued gabapentin treatment, 5 of whom remain seizure free and side effect free with gabapentin monotherapy. Of the 42 patients discontinuing treatment, 17 had no seizure reduction, 17 had side effects, and 8 had both. One additional patient died. The mean daily dosage for all 100 patients was 2107 mg, and the mean daily dosage for patients who continued gabapentin treatment was 2270 mg. No linear relationship was found between dosage and patient weight. Fifty-two patients had the dosage of at least 1 concomitant antic...Continue Reading

Citations

Apr 3, 1999·Medicinal Research Reviews·J S Bryans, D J Wustrow
Feb 24, 2001·Journal of the American Dietetic Association·B McGhee, N Katyal
Jul 27, 2001·Neurologic Clinics·S C Schachater
Apr 20, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J HatzimanolisG N Christodoulou
Feb 15, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·L Reisner, C A Pettengill
Oct 26, 1999·Epilepsia·G L Morris
Aug 3, 2002·CNS Drugs·Abouch V KrymchantowskiPedro F Moreira
Nov 14, 2014·CNS Drugs·J van GaalenB P C van de Warrenburg
Feb 11, 2000·Seizure : the Journal of the British Epilepsy Association·P K Datta, P M Crawford
Mar 21, 2008·Epilepsy & Behavior : E&B·M CarreñoJ Porcel
Dec 14, 2005·Critical Reviews in Oncology/hematology·Constantijne H MomElisabeth G E de Vries
Jul 10, 2013·Anesthesiology·Richard RauckLinda M Page

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