Efficacy and tolerability of limited field radiotherapy with concurrent capecitabine in locally advanced pancreatic cancer

Clinical Oncology : a Journal of the Royal College of Radiologists
A S N JacksonA Saleem

Abstract

Patients with locally advanced pancreatic cancer (LAPC) are most commonly managed with chemotherapy or concurrent chemoradiotherapy (CRT), which may or may not include non-involved regional lymph nodes in the clinical target volume. We present our results of CRT for LAPC using capecitabine and delivering radiotherapy to a limited radiation field that excluded non-involved regional lymph nodes from the clinical target volume. Thirty patients were studied. Patients received 50.4 Gy external beam radiotherapy in 28 fractions, delivered to a planning target volume expanded from the primary tumour and involved nodes only. Capecitabine (500-600 mg/m2) was given twice daily continuously during radiotherapy. Toxicity and efficacy data were prospectively collected. Nausea, vomiting and tumour pain were the most common grade 2 toxicities. One patient developed grade 3 nausea. The median time to progression was 8.8 months, with 20% remaining progression free at 1 year. The median overall survival was 9.7 months with a 1 year survival of 30%. Of 21 patients with imaged progression, 13 (62%) progressed systemically, three (14%) had local progression, two (10%) had locoregional progression and three (14%) progressed with both local/locoregio...Continue Reading

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Citations

Nov 7, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Erkan TopkanFuat Yapar
Apr 11, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Alejandro RopoloMaria I Vaccaro
Sep 10, 2014·BioMed Research International·Claudio D GonzalezMaria I Vaccaro
Aug 1, 2015·Hematology/oncology Clinics of North America·Erqi L PollomAndrew H Ko
Apr 22, 2015·International Journal of Radiation Oncology, Biology, Physics·Eelco LensArjan Bel
Jul 10, 2012·International Journal of Radiation Oncology, Biology, Physics·Florence HuguetRoss A Abrams
Jan 18, 2013·Prostate Cancer·Matthew E Johnson, Mark K Buyyounouski

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