Abstract
The antihypertensive effects and the tolerability of losartan and enalapril given alone or in combination with hydrochlorothiazide (HCTZ) were compared in a multicenter, double-blind, randomized, parallel-group, 16-week clinical trial. The study consisted of a 4-week placebo washout phase and a 12-week active treatment phase. Patients with mild-to-moderate, uncomplicated essential hypertension were considered for participation in the study. To enter the treatment phase of the study, a mean sitting diastolic blood pressure (SiDBP) > or = 95 and < or = 115 mm Hg was required. Patients received either 50-mg losartan once daily or 5-mg enalapril once daily at randomization. The dose of enalapril could be titrated to 10 mg after 4 weeks and 25 mg of HCTZ could be added after 8 weeks, based on measurements of SiDBP at clinic visits. The dose of losartan remained at 50 mg; 12.5 mg of HCTZ could be added after 8 weeks. Changes in the treatment regimen at each step were required if SiDBP remained > or = mm Hg. Doses of the diuretic were chosen based on commercially available forms of the test agents in combination with HCTZ. Trough blood pressure, heart rate, and safety parameters were measured at 4-week intervals during the treatment p...Continue Reading
References
Mar 24, 1977·The New England Journal of Medicine·D B CaseJ H Laragh
Mar 1, 1977·Circulation Research·G H AndersonT G Dalakos
May 31, 1976·The American Journal of Medicine·D B CaseJ H Laragh
Aug 1, 1992·Annals of Internal Medicine·Z H Israili, W D Hall
Jun 1, 1991·The Tohoku Journal of Experimental Medicine·U KatsumataT Takishima
Dec 8, 1988·The New England Journal of Medicine·G H Williams
May 1, 1972·The American Journal of Medicine·J H LaraghE D Vaughan
Jun 1, 1984·Kidney International·R M Zusman
Apr 24, 1981·European Journal of Pharmacology·T UngerD Ganten
Jul 1, 1995·Hypertension·B A SofferC S Sweet
Dec 1, 1994·Journal of Hypertension·Y LacourcièreE B Nelson
Jun 1, 1995·Hypertension·A H GradmanC S Sweet
Nov 1, 1994·Journal of Clinical Pharmacology·D RavidM Ravid
May 1, 1993·Hypertension·M R GoldbergT D Bjornsson
Citations
Aug 18, 2004·Advances in Therapy·Massimo Volpe
Dec 8, 2011·Journal of General Internal Medicine·Benjamin J PowersGillian D Sanders
Sep 12, 2000·Current Hypertension Reports·M E Fabiani, C I Johnston
Jul 1, 1997·Clinical Therapeutics·M Weber
Apr 8, 2003·Journal of the American College of Cardiology·John M FlackElijah Saunders
Jun 1, 1997·Journal of the American College of Cardiology·M Moser
Nov 18, 1998·Current Opinion in Nephrology and Hypertension·N Perico, G Remuzzi
Dec 25, 2004·International Journal of Clinical Practice. Supplement·L AlcocerC Segovia-Ayala
Nov 26, 2010·Blood Pressure. Supplement·Jean-Michel MallionUNKNOWN Study Group
Nov 3, 2010·The American Journal of Medicine·Sripal BangaloreFranz H Messerli
Feb 22, 2005·The Journal of Clinical Hypertension·Paolo Palatini
Nov 26, 1999·Clinical and Experimental Hypertension : CHE·P HoweK Kassler-Taub
Sep 19, 2009·Expert Opinion on Drug Metabolism & Toxicology·Masanori AbeKoichi Matsumoto
Mar 12, 2004·Expert Opinion on Pharmacotherapy·Steven G Chrysant, George S Chrysant
Feb 24, 2001·Journal of Receptor and Signal Transduction Research·M J Robertson
Oct 30, 1998·The Annals of Pharmacotherapy·G B Pylypchuk
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·M S WeinbergD H Zappe
Aug 10, 2002·Current Hypertension Reports·Norman K Hollenberg
Jan 22, 2005·Journal of Human Hypertension·S G ChrysantA Desai
Sep 11, 2010·Journal of Hypertension·Ettore MalaccoUNKNOWN ESPORT Study Group
Jan 5, 2002·Journal of Human Hypertension·E BreezeA E Fletcher
Mar 6, 1999·Journal of Hypertension·B E KarlbergK Hermansson
Jan 19, 2002·Hypertension·Juerg NussbergerHans R Brunner
May 29, 2000·American Journal of Hypertension·K MalmqvistM Dahl
Dec 24, 2005·The Journal of International Medical Research·J M Neutel, D Smith