PMID: 8595643Sep 1, 1995Paper

Efficacy and tolerability of losartan versus enalapril alone or in combination with hydrochlorothiazide in patients with essential hypertension

Clinical Therapeutics
R R TownsendJ M Edelman

Abstract

The antihypertensive effects and the tolerability of losartan and enalapril given alone or in combination with hydrochlorothiazide (HCTZ) were compared in a multicenter, double-blind, randomized, parallel-group, 16-week clinical trial. The study consisted of a 4-week placebo washout phase and a 12-week active treatment phase. Patients with mild-to-moderate, uncomplicated essential hypertension were considered for participation in the study. To enter the treatment phase of the study, a mean sitting diastolic blood pressure (SiDBP) > or = 95 and < or = 115 mm Hg was required. Patients received either 50-mg losartan once daily or 5-mg enalapril once daily at randomization. The dose of enalapril could be titrated to 10 mg after 4 weeks and 25 mg of HCTZ could be added after 8 weeks, based on measurements of SiDBP at clinic visits. The dose of losartan remained at 50 mg; 12.5 mg of HCTZ could be added after 8 weeks. Changes in the treatment regimen at each step were required if SiDBP remained > or = mm Hg. Doses of the diuretic were chosen based on commercially available forms of the test agents in combination with HCTZ. Trough blood pressure, heart rate, and safety parameters were measured at 4-week intervals during the treatment p...Continue Reading

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Citations

Aug 18, 2004·Advances in Therapy·Massimo Volpe
Sep 12, 2000·Current Hypertension Reports·M E Fabiani, C I Johnston
Jul 1, 1997·Clinical Therapeutics·M Weber
Apr 8, 2003·Journal of the American College of Cardiology·John M FlackElijah Saunders
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Oct 30, 1998·The Annals of Pharmacotherapy·G B Pylypchuk

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