Efficacy and tolerability of lumiracoxib, a highly selective cyclo-oxygenase-2 (COX2) inhibitor, in the management of pain and osteoarthritis.

Therapeutics and Clinical Risk Management
Piet Geusens, W F Lems

Abstract

Lumiracoxib is a COX2 inhibitor that is highly selective, is more effective than placebo on pain in osteoarthritis (OA), with similar analgesic and anti-inflammatory effects as non-selective NSAIDs and the selective COX2 inhibitor celecoxib, has a lower incidence of upper gastrointestinal (GI) side effects in patients not taking aspirin, and a similar incidence of cardiovascular (CV) side effects compared to naproxen or ibuprofen. In the context of earlier guidelines and taking into account the GI and CV safety results of the TARGET study, lumiracoxib had secured European Medicines Agency (EMEA) approval with as indication symptomatic treatment of OA as well as short-term management of acute pain associated with primary dysmenorrhea and following orthopedic or dental surgery. In the complex clinical context of efficiency and safety of selective and non-selective COX inhibitors, its prescription and use should be based on the risk and safety profile of the patient. In addition, there is further need for long-term GI and CV safety studies and general post-marketing safety on its use in daily practice. Meanwhile, at the time of submission of this manuscript, the EMEA has withdrawn lumiracoxib throughout Europe because of the risk ...Continue Reading

Citations

Apr 28, 2009·Expert Opinion on Biological Therapy·Piet Geusens
Dec 2, 2009·Inflammopharmacology·K D Rainsford
Jun 12, 2013·Internal Medicine Journal·K C FokB E Jones
Mar 30, 2017·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Dixon ThomasJason C Cooper
Jan 3, 2019·Inflammopharmacology·Kizhakkeppurath Kumaran AjeeshkumarGopinathan Pillai Sreekanth
Aug 22, 2020·Journal of Pain Research·Kok Yuen HoErnest Choy
Mar 11, 2009·The Journal of Experimental Medicine·Katia BonifaceRené de Waal Malefyt

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