Efficacy and tolerability of mycophenolate mofetil in a pediatric Rasmussen syndrome

Epilepsy & Behavior Reports
A OrsiniA Bonuccelli

Abstract

Rasmussen syndrome (RS) is a chronic encephalopathy with uncertain etiology and immune-mediated pathogenesis. The only definitive treatment is represented by functional hemispherectomy. We describe the case of a 6.5-year-old female patient who developed several episodes of focal, unilateral clonic seizures. Following laboratory and instrumental investigations, the patient was diagnosed as having RS. A treatment with corticosteroids, intravenous immunoglobulin, and the antiseizure medication (carbamazepine and levetiracetam) did not completely control the seizures. Therefore, the patient was treated with mycophenolate mofetil (MMF), showing a good clinical response, with reduction of the seizures, and stability of the radiological findings. This case suggests the potential utility of MMF in the immune approach to RS.

Citations

Dec 10, 2020·Therapeutic Advances in Chronic Disease·Chongyang TangTianfu Li

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Methods Mentioned

BETA
biopsy

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