PMID: 9660522Jul 11, 1998Paper

Efficacy and tolerability of once-daily barnidipine in the clinical management of patients with mild to moderate essential hypertension

Blood Pressure. Supplement
C Spieker

Abstract

Four multicentre trials have investigated the efficacy and tolerability of treatment with once-daily, modified-release capsules of barnidipine, a long-acting dihydropyridine calcium antagonist, in patients with mild to moderate essential hypertension. In two of these trials, the clinical profile of barnidipine was compared with those of amlodipine and nitrendipine, which belong to the same class of drug as barnidipine, in a randomized, double-blind, parallel-group manner. In one study, 37 patients received amlodipine and 79 patients received barnidipine. In a second study, 46 patients received nitrendipine and 96 received barnidipine. In each trial, a 4-week placebo run-in phase was followed by a 12-week comparative phase. Changes in sitting and standing diastolic and systolic blood pressures were assessed, and adverse events were recorded. Both studies demonstrated that the antihypertensive efficacy of barnidipine was equivalent to each comparator agent, but barnidipine tended to produce fewer class I adverse reactions. The long-term efficacy and safety of barnidipine were demonstrated in an open-label study. In total, 106 patients were followed for the first year of the study, during which time they received barnidipine at a ...Continue Reading

Citations

Jul 5, 2005·Expert Opinion on Investigational Drugs·D F Cummins
Sep 23, 2006·The Journal of International Medical Research·W ZhuM Yamamoto
Jan 7, 2017·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Robert LinsCaroline de Vries
Jul 4, 2001·Drugs·H S Malhotra, G L Plosker
Apr 15, 2004·The Journal of International Medical Research·P BuranakitjaroenC Chawantanpipat
Aug 9, 2002·The Journal of International Medical Research·C S LiauT M Lee

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